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Synthetic Communications

Synthetic Communications

IF: 1.8
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Synthesis of 2-Aminobenzophenone Derivatives and Their Anticancer Activity

Published:1 January 2012 DOI: 10.1080/00397911.2010.521435
Sandra Cortez-Maya,?E. Cortés,?S. Hernández-Ortega,?T. R. Apan,?M. Marti?nez-Garci?a

Abstract

Abstract A number of 2-aminobenzophenones have been synthesized by acylation of para-chloroaniline with different 2-, 3-, 4-chloro- or fluorobenzoyl chloride in solid state via the Friedel–Crafts reaction. Synthesized compounds were characterized by 1H and 13C NMR, Fourier transform–infrared, ultraviolet–visible spectroscopy, mass spectrometry, and elemental analysis. Evaluation of biological activity in vitro showed that the selected compounds 9, 10, and 13 have potential anticancer activity. The presence of one chlorine atom in the second aromatic ring of the benzophenone molecule makes it more active. GRAPHICAL ABSTRACT

Substances (9)

Related products
Procduct Name CAS Molecular Formula Supplier Price
4-Fluorobenzoyl chloride 403-43-0 C7H4ClFO 591 suppliers $9.00-$6480.57
4-Chloroaniline 106-47-8 C6H6ClN 555 suppliers $5.00-$6404.90
2-Aminobenzophenone 2835-77-0 C13H11NO 538 suppliers $5.00-$1068.00
4-Chlorobenzoyl chloride 122-01-0 C7H4Cl2O 445 suppliers $7.62-$1258.95
3-Chlorobenzoyl chloride 618-46-2 C7H4Cl2O 438 suppliers $9.00-$2362.40
2-Chlorobenzoyl chloride 609-65-4 C7H4Cl2O 417 suppliers $21.00-$1166.55
Keratin 13 15 suppliers Inquiry
1-(1-Chloroethyl)-2-methylbenzene 55968-39-3 C9H11Cl 10 suppliers Inquiry
Topiroxostat Impurity 10 3 suppliers Inquiry

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