一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

ChemicalBook >> journal list >> Advanced Materials >>article
Advanced Materials

Advanced Materials

IF: 27.4
Download PDF

Biomimetic Nanomotors for Deep Ischemia Penetration and Ferroptosis Inhibition in Neuroprotective Therapy of Ischemic Stroke

Published:26 November 2024 DOI: 10.1002/adma.202409176 PMID: 39600046
Rui Wang, Weimin Nie, Xin Yan, Kuankuan Luo, Qi Zhang, Tao Wang, Enhao Lu, Yiting Chen, Yu Luo, Zhiwen Zhang, He Wang, Jing Zhao, Xianyi Sha

Abstract

Nerve injury represents the primary reason of mortality and disability in ischemic stroke, but effective drug delivery to the region of cerebral ischemia and hypoxia poses a significant challenge in neuroprotective treatment. To address these clinical challenges, a biomimetic nanomotor, Pt@LF is designed, to facilitate deep delivery of neuroprotective agents and inhibit ferroptosis in ischemic stroke. Pt@LF traverses the blood-brain barrier (BBB) and penetrates into deep cerebral ischemic-hypoxic areas due to the active targeting capacity of apo-lactoferrin (Apo-LF) and the self-propelling motion properties of nanomotors. Subsequently, Pt@LF loosens thrombus and alleviates the "no reflow" phenomenon via mechanical thrombolysis. Thanks to the various enzyme-like abilities and multi-target ferroptosis inhibition capability, Pt@LF ameliorates the inflammatory microenvironment and rescues dying neurons. In conclusion, Pt@LF demonstrates efficiently deep penetration and neuroprotective effects in vitro and vivo. And this study provides a promising therapeutic platform for the treatment of ischemic stroke.

Substances (5)

Materials
Procduct Name CAS Molecular Formula Supplier Price
4',6-Diamidino-2-phenylindole dihydrochloride 28718-90-3 C16H16ClN5 617 suppliers $15.00-$4800.00
Fluorescein isothiocyanate isomer I 3326-32-7 C21H11NO5S 558 suppliers $16.00-$8352.40
2′,7′-Dichlorodihydrofluorescein Diacetate 4091-99-0 C24H16Cl2O7 292 suppliers $16.00-$270980.00
RSL3 1219810-16-8 C23H21ClN2O5 218 suppliers $13.00-$2492.00
JC-1 3520-43-2 C25H27Cl4N4.I 188 suppliers $42.00-$3900.00

Similar articles

IF:2.9

Neuroprotective Effects of Ginkgolide B Against Ischemic Stroke: A Review of Current Literature.

Current topics in medicinal chemistry Seyed Mohammad Nabavi, Solomon Habtemariam,etc Published: 1 January 2015
IF:3

Neuroprotective effects of phenylacetylglycine via β2AR on cerebral ischemia/reperfusion injury in rats

Saudi Pharmaceutical Journal Wenjie Hu, Xueyan Kuang,etc Published: 1 December 2024
IF:18.5

X‐Ray‐Triggered CA IX Inhibition Nanoplatform Promotes Intratumoral Acidosis‐Induced Cancer Ferroptosis

Advanced Functional Materials Yuanyuan You, Wenxiao Jiang,etc Published: 20 November 2024
沙洋县| 大悟县| 海淀区| 阿拉尔市| 焦作市| 芦溪县| 龙江县| 凤山市| 西安市| 隆化县| 天峨县| 家居| 巫山县| 滨州市| 左权县| 贵溪市| 黄骅市| 东城区| 金湖县| 福鼎市| 大姚县| 黎城县| 石河子市| 阳山县| 弥勒县| 泾阳县| 安康市| 永福县| 青州市| 山东省| 修水县| 武清区| 佛山市| 平阴县| 西藏| 内黄县| 临朐县| 澳门| 蕉岭县| 渝中区| 屏东县|