一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

ChemicalBook >> journal list >> Saudi Pharmaceutical Journal >>article
Saudi Pharmaceutical Journal

Saudi Pharmaceutical Journal

IF: 3
Download PDF

Neuroprotective effects of phenylacetylglycine via β2AR on cerebral ischemia/reperfusion injury in rats

Published:1 December 2024 DOI: 10.1016/j.jsps.2024.102210
Wenjie Hu, Xueyan Kuang, Litao Zhang

Abstract

Phenylacetylglycine (PAGly) is a small molecule derived from phenylalanine in the gut via glycine degradation and conjugation. It has been associated with both the progression of atherosclerosis and protective effects on the myocardium. This study evaluated the function and the underlying mechanisms of PAGly in a rat cerebral ischemia/reperfusion (I/R) injury model. The results indicated that PAGly markedly alleviated cerebral infarct volume (P?=?0.0024) and improved the neurobehavioral outcomes (P = 0.0149) after I/R injury. PAGly is structurally analogous to catecholamines and binds to β2-adrenergic receptors (β2AR) on microglia without altering the expression of these receptors (P = 0.9137), but instead inhibiting their activity. It was also observed that when β2AR was engaged in microglia, PAGly suppressed the release of TNF-α (P = 0.0018), IL-1β (P = 0.0310), and IL-6 (P = 0.0017), thereby reducing neuronal apoptosis (P?=?0.000003). Furthermore, the protective effect of PAGly diminished after the administration of β2AR-specific agonist fenoterol (P = 0.0055). These data indicate that PAGly mitigates cerebral I/R injury by inhibiting microglial inflammation via β2AR, highlighting its potential as a therapeutic agent. These findings position PAGly as a promising candidate for therapeutic intervention in cerebrovascular injuries, warranting further exploration in clinical settings.

Similar articles

IF:6.2

Neuroprotective effects of Ginkgo biloba extract.

Cellular and Molecular Life Sciences B Ahlemeyer,?J Krieglstein,etc Published: 1 September 2003
衡阳县| 河池市| 通许县| 永登县| 时尚| 麻栗坡县| 定西市| 唐海县| 永登县| 洪泽县| 灵寿县| 科技| 鞍山市| 宽城| 祁门县| 克什克腾旗| 岳阳市| 罗甸县| 开封县| 漳浦县| 丹东市| 曲沃县| 乌拉特前旗| 九台市| 金乡县| 兴城市| 天等县| 从化市| 仁化县| 澄江县| 新和县| 白水县| 呈贡县| 宣城市| 会泽县| 蚌埠市| 麦盖提县| 嘉义市| 和田市| 吉水县| 佳木斯市|