一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

ChemicalBook >> journal list >> Iranian Journal of Basic Medical Sciences >>article
Iranian Journal of Basic Medical Sciences

Iranian Journal of Basic Medical Sciences

IF: 2.1
Download PDF

The cardioprotective effect of vanillic acid on hemodynamic parameters, malondialdehyde, and infarct size in ischemia-reperfusion isolated rat heart exposed to PM10.

Published:1 July 2017 DOI: 10.22038/IJBMS.2017.9007 PMID: 28852440
Esmat Radmanesh, Mahin Dianat, Mohammad Badavi, Gholamreza Goudarzi, Seyyed Ali Mard

Abstract

Objectives: Particulate matter (PM) exposure can promote cardiac ischemia and myocardial damage. The effects of PM10 on hemodynamic parameters, lipid peroxidation, and infarct size induced by ischemia-reperfusion injury and the protective effects of vanillic acid (VA) in isolated rat heart were investigated.

Materials and methods: Eighty male Wistar rats (250-300 g) were divided into 8 groups (n=10): Control, Sham, VAc, VA, PMa (0.5 mg/kg PM, intratracheal instillation), PMb (2.5 mg/kg PM, intratracheal instillation), PMc (5 mg/kg PM, intratracheal instillation), and PMc + VA (5 mg/kg PM, intratracheal instillation; and 10 mg/kg vanillic acid, gavage for 10 days). PM10 was instilled into the trachea in two stages, within 48 hr. After isolating the hearts and transfer to a Langendorff apparatus, hearts were subjected to 30 min ischemia and 60 min reperfusion. Hemodynamic parameters (±dp/dt, LVSP, LVDP, and RPP), production of lipid peroxidation (MDA), and infarct size were assessed.

Results: A significant decrease in ±dp/dt, LVSP, LVDP and RPP occurred in PM groups. A significant increase in MDA and myocardial infarct size occurred in PM groups. A significant increase in LVDP, LVSP, ±dp/dt, RPP and decrease in infarct size, MDA, and myocardial dysfunction was observed in groups that received vanillic acid after ischemia-reperfusion.

Conclusion: It was demonstrated that PM10 increases MDA, as well as the percentage of cardiac infarct size, and has negative effects on hemodynamic parameters. This study suggests that vanillic acid may serve as an adjunctive treatment in delaying the progression of ischemic heart disease.

Substances (3)

Related products
Procduct Name CAS Molecular Formula Supplier Price
Vanillic acid 121-34-6 C8H8O4 709 suppliers $6.00-$4147.28
4,4'-Methylenedianiline 101-77-9 C13H14N2 413 suppliers $15.00-$1559.25
PM10 detection standard substances 1 suppliers Inquiry

Similar articles

IF:3

Neuroprotective effects of phenylacetylglycine via β2AR on cerebral ischemia/reperfusion injury in rats

Saudi Pharmaceutical Journal Wenjie Hu, Xueyan Kuang,etc Published: 1 December 2024
台北市| 白沙| 老河口市| 获嘉县| 江永县| 兴山县| 漠河县| 察哈| 云林县| 云阳县| 长乐市| 钟祥市| 东城区| 新津县| 棋牌| 韶山市| 临猗县| 随州市| 当雄县| 西乌珠穆沁旗| 新泰市| 武胜县| 长武县| 岳普湖县| 上虞市| 微山县| 广宁县| 凌云县| 大新县| 东方市| 津市市| 临朐县| 澳门| 南皮县| 民县| 泽库县| 湄潭县| 通江县| 呈贡县| 天镇县| 改则县|