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International journal of oncology

International journal of oncology

IF: 4.5
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Antimicrobial agent chloroxylenol targets β?catenin?mediated Wnt signaling and exerts anticancer activity in colorectal cancer.

Published:1 November 2023 DOI: 10.3892/ijo.2023.5569 PMID: 37681484
Qi Sun, Boxin Liu, Quanxue Lan, Zijie Su, Qiuxia Fu, Lian Wang, Yingying Deng, Chuanli Li, Vivian Weiwen Xue, Shanshan Liu, Xianxiong Chen, Guowu Yang, Desheng Lu

Abstract

Chloroxylenol is the active ingredient of the antibacterial agent Dettol. The anticancer effect and underlying mechanisms of this compound and other common antimicrobial agents have not been clearly elucidated. In the present study, the effects of chloroxylenol, benzalkonium chloride, benzethonium chloride, triclosan and triclocarban on β?catenin?mediated Wnt signaling in colorectal cancer were evaluated using the SuperTOPFlash reporter assay. It was demonstrated that chloroxylenol, but not the other antimicrobial agents tested, inhibited the Wnt/β?catenin signaling pathway by decreasing the nuclear translocation of β?catenin and disrupting β?catenin/T?cell factor 4 complex, which resulted in the downregulation of the Wnt target genes Axin2, Survivin and Leucine?rich G protein?coupled receptor?5. Chloroxylenol effectively inhibited the viability, proliferation, migration and invasion, and sphere formation, and induced apoptosis in HCT116 and SW480 cells. Notably, chloroxylenol attenuated the growth of colorectal cancer in the MC38 cell xenograft model and inhibited organoid formation by the patient?derived cells. Chloroxylenol also demonstrated inhibitory effects on the stemness of colorectal cancer cells. The results of the present study demonstrated that chloroxylenol could exert anti?tumor activities in colorectal cancer by targeting the Wnt/β?catenin signaling pathway, which provided an insight into its therapeutic potential as an anticancer agent.

Substances (9)

Related products
Procduct Name CAS Molecular Formula Supplier Price
Triclosan 3380-34-5 C12H7Cl3O2 786 suppliers $5.00-$1593.90
Benzethonium chloride 121-54-0 C27H42ClNO2 732 suppliers $5.00-$980.00
4-Chloro-3,5-dimethylphenol 88-04-0 C8H9ClO 689 suppliers $5.00-$1490.00
Benzalkonium Chloride 63449-41-2 C17H30ClN 631 suppliers $12.00-$2790.00
Triclocarban 101-20-2 C13H9Cl3N2O 540 suppliers $6.00-$1380.00
Survivin 45 suppliers Inquiry
chloroxylenol 1321-23-9 C8H9ClO 23 suppliers Inquiry
Axin2 18 suppliers Inquiry
Orphan G-protein coupled receptor HG38 17 suppliers Inquiry

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