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ACS Applied Energy Materials

ACS Applied Energy Materials

IF: 5.4
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Sodium butyrate in both prevention and supportive treatment of colorectal cancer.

Published:26 October 2022 DOI: 10.3389/fcimb.2022.1023806 PMID: 36389140
Karolina Ka?mierczak-Siedlecka, Luigi Marano, Elvira Merola, Franco Roviello, Karol Po?om

Abstract

Accumulating evidence suggests that selected microbiota-derived metabolites play a significant role in both tumor prevention and supportive treatment of cancer. Short-chain fatty acids (SCFAs), i.e., mainly acetate, proprionate, and butyrate, are one of them. Nowadays, it is known that butyrate is a key microbial metabolite. Therefore, in the current review, we focused on butyrate and sodium butyrate (NaB) in the context of colorectal cancer. Notably, butyrate is characterized by a wide range of beneficial properties/activities. Among others, it influences the function of the immune system, maintains intestinal barrier integrity, positively affects the efficiency of anti-cancer treatment, and may reduce the risk of mucositis induced by chemotherapy. Taking into consideration these facts, we analyzed NaB (which is a salt of butyric acid) and its impact on gut microbiota as well as anti-tumor activity by describing molecular mechanisms. Overall, NaB is available as, for instance, food with special medical purposes (depending on the country's regulation), and its administration seems to be a promising option for colorectal cancer patients.

Substances (2)

Related products
Procduct Name CAS Molecular Formula Supplier Price
Butyric Acid 107-92-6 C4H8O2 662 suppliers $7.62-$4100.00
Sodium Butyrate 156-54-7 C4H7NaO2 628 suppliers $5.00-$980.00

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