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American journal of veterinary research

American journal of veterinary research

IF: 1.3
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Efficacy of sodium iodide for prevention of respiratory disease in preweaned dairy calves.

Published:1 August 2020 DOI: 10.2460/ajvr.81.8.673 PMID: 32700995
Lisa Gamsj?ger, Brian L Vander Ley, Heather K Knych, Gary R McArthur, Meera C Heller

Abstract

Objective: To determine the pharmacokinetics of sodium iodide (NaI) following oral administration to preweaned dairy calves, and to assess the efficacy of NaI for prevention of bovine respiratory disease (BRD) in preweaned calves at a commercial calf-raising facility.

Animals: 434 healthy preweaned dairy calves.

Procedures: In the first of 2 experimental trials, each of 7 calves received NaI (20 mg/kg, PO) once. Blood and nasal fluid samples were collected at predetermined times before (baseline) and for 72 hours after NaI administration for determination of iodine concentrations. Pharmacokinetic parameters were determined by noncompartmental analysis. In the second trial, 427 calves at a calf-raising facility were randomly assigned to receive NaI (20 mg/kg, PO, 2 doses 72 hours apart; n = 211) or serve as untreated controls (216). Health outcomes were compared between the 2 groups.

Results: For all 7 calves in the pharmacokinetic trial, the iodine concentration in both serum and nasal fluid samples was significantly increased from the baseline concentration and exceeded the presumed therapeutic iodine concentration (6.35 μg/mL) throughout the sampling period. In the on-farm trial, the odds of being treated for BRD before weaning for NaI-treated calves were twice those for control calves (OR, 2.04; 95% CI, 1.38 to 3.00).

Conclusions and clinical relevance: Results suggested that, although oral administration of NaI (20 mg/kg) to preweaned dairy calves achieved iodine concentrations presumed to be effective in both serum and nasal fluid, it was not effective for prevention of BRD in preweaned calves at a commercial calf-raising facility.

Substances (3)

Related products
Procduct Name CAS Molecular Formula Supplier Price
Sodium iodide 7681-82-5 NaI 799 suppliers $10.00-$4750.00
1-Acetylimidazole 2466-76-4 C5H6N2O 445 suppliers $10.00-$2245.00
iodine 12190-71-5 I2 322 suppliers Inquiry

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