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Cell Death and Differentiation

Cell Death and Differentiation

IF: 15.4
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CCL2 regulation of MST1-mTOR-STAT1 signaling axis controls BCR signaling and B-cell differentiation.

Published:20 April 2021 DOI: 10.1038/s41418-021-00775-2 PMID: 33879857
Lu Yang, Na Li, Di Yang, Anwei Chen, Jianlong Tang, Yukai Jing, Danqing Kang, Panpan Jiang, Xin Dai, Li Luo, Qiuyue Chen, Jiang Chang, Ju Liu, Heng Gu, Yanmei Huang, Qianglin Chen, Zhenzhen Li, Yingzi Zhu, Heather Miller, Yan Chen, Liru Qiu, Heng Mei, Yu Hu, Quan Gong, Chaohong Liu

Abstract

Chemokines are important regulators of the immune system, inducing specific cellular responses by binding to receptors on immune cells. In SLE patients, decreased expression of CCL2 on mesenchymal stem cells (MSC) prevents inhibition of B-cell proliferation, causing the characteristic autoimmune phenotype. Nevertheless, the intrinsic role of CCL2 on B-cell autoimmunity is unknown. In this study using Ccl2 KO mice, we found that CCL2 deficiency enhanced BCR signaling by upregulating the phosphorylation of the MST1-mTORC1-STAT1 axis, which led to reduced marginal zone (MZ) B cells and increased germinal center (GC) B cells. The abnormal differentiation of MZ and GC B cells were rescued by in vivo inhibition of mTORC1. Additionally, the inhibition of MST1-mTORC1-STAT1 with specific inhibitors in vitro also rescued the BCR signaling upon antigenic stimulation. The deficiency of CCL2 also enhanced the early activation of B cells including B-cell spreading, clustering and signalosome recruitment by upregulating the DOCK8-WASP-actin axis. Our study has revealed the intrinsic role and underlying molecular mechanism of CCL2 in BCR signaling, B-cell differentiation, and humoral response.

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