一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

ChemicalBook >> journal list >> EFSA Journal >>article
EFSA Journal

EFSA Journal

IF: 3.29
Download PDF

Scientific Opinion on the re-evaluation of erythorbic acid (E 315) and sodium erythorbate (E 316) as food additives

Published:20 January 2016 DOI: 10.2903/j.efsa.2016.4360
EFSA Panel on Food Additives and Nutrient Sources added to food (ANS)

Abstract

The EFSA Panel on Food Additives and Nutrient Sources added to Food (ANS) provides a scientific opinion re-evaluating the safety of erythorbic acid (E 315) and sodium erythorbate (E 316) as food additives. The use of these food additives was evaluated by the Scientific Committee on Food (SCF) that established an acceptable daily intake (ADI) of 6 mg/kg body weight (bw)/day. Intestinal absorption of erythorbate was reported from a mice study and near complete excretion within 24 h from a guinea pig study. The Panel noted that the acute toxicity of erythorbic acid or sodium erythorbate is low, there was no indication of adverse effects from the available subchronic toxicity studies, there is no concern with respect to their genotoxicity neither to respect to carcinogenicity. The Panel identified a no observed adverse effect level (NOAEL) of 650 mg/kg bw/day based on a decrease in body weight from a carcinogenicity study. No maternal and developmental effects were observed from a prenatal developmental toxicity study with sodium erythorbate. The Panel recognised the limitation of the overall toxicological database (no reproductive and chronic toxicity studies), but did not consider necessary to increase the usual uncertainty factor of 100 in deriving an ADI. Therefore, the Panel concluded that there is no reason to revise the current ADI of 6 mg/kg bw/day. Combined dietary exposure to erythorbic acid and sodium erythorbate from their use as food additives was calculated. Considering that the ADI is not exceeded by any population group, the Panel also concluded that the use of erythorbic acid (E 315) and sodium erythorbate (E 316) as food additives at the permitted or reported use and use levels would not be of safety concern.

Substances (3)

Related products
Procduct Name CAS Molecular Formula Supplier Price
Erythorbic Acid 89-65-6 C6H8O6 588 suppliers $12.00-$474.00
Sodium erythorbate 6381-77-7 C6H9NaO6 500 suppliers $10.00-$4296.41
SODIUM ERYTHORBATE 7378-23-6 C6H9NaO6 189 suppliers Inquiry

Similar articles

IF:0

Monomethyl Auristatin E

Definitions Published: 2 February 2020
IF:3.3

Scientific Opinion on the safety and efficacy of vitamin A (retinyl acetate, retinyl palmitate and retinyl propionate) as a feed additive for all animal species and categories

EFSA Journal EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP),etc Published: 8 January 2013
IF:0

Expression of Cloned Genes in E. coli Using IPTG-inducible Promoters.

CSH protocols Joseph Sambrook, David W Russell,etc Published: 1 June 2006
枝江市| 宜黄县| 张家界市| 屯门区| 教育| 怀来县| 甘肃省| 扶绥县| 福贡县| 衡南县| 普兰店市| 清徐县| 桃江县| 农安县| 西乌珠穆沁旗| 鹤峰县| 遂川县| 南雄市| 木兰县| 宁陵县| 特克斯县| 宜宾市| 隆尧县| 诸暨市| 武宣县| 灵武市| 绥芬河市| 南木林县| 阿克陶县| 安新县| 宜城市| 濮阳市| 漠河县| 缙云县| 饶阳县| 化德县| 石泉县| 上林县| 双牌县| 伊金霍洛旗| 修文县|