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Environmental Science and Pollution Research

Environmental Science and Pollution Research

IF: 5.8
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Bisphenol A exposure decreases sperm production and male fertility through inhibition PCBP2 expression

Published:20 November 2023 DOI: 10.1007/s11356-023-30815-y PMID: 37985585
Yuming Cao, Jinfeng Xu, Jie Liu, Yan Liang, Fei Ao, Shengnan Wang, Zexiao Wei, Li Wang

Abstract

Growing evidence suggests that the exposure of bisphenol A (BPA), an endocrine disruptor that commonly present in the environment, can impair reproduction. However, conflicting results have been reported, and the underlying mechanism has not been fully understood. In this study, 3-week-old male mice were oral exposed to 50?mg/kg/d BPA or equivalent corn oil for 28?days. Their testis and epididymis were then collected for morphology examination by HE stains. The number of sperm was counted, and the morphology was analyzed by PNA (peptide nucleic acid) and pap staining. Fertilization capacity and successful rate were analyzed after mating with wide-type females. Spermatid DNA damage and apoptosis were evaluated by DFI, γH2AX stain, and TUNEL assay. RNA sequencing analysis was conducted to identify differentially expressed genes in testicular tissue of mice exposed to BPA. RNA interference was used to verify the regulatory mechanism of BPA exposure on gene expression in GC-2 cells. Our data showed that the total number of sperm was decreased and the morphology was impaired in BPA-exposed mice. In addition, the serum testosterone level and fertilization efficiency were also reduced. Mechanism studies showed that BPA could suppress the expression of PCBP2, a key regulatory gene in spermatid development, by activating the EZH2/H3K27me3. In conclusion, we found that BPA exposure can impair spermatid development via affecting key gene expression that is at least partially due to epigenetic modification.

Substances (6)

Materials
Procduct Name CAS Molecular Formula Supplier Price
Bisphenol A 80-05-7 C15H16O2 793 suppliers $10.00-$1593.90
Bisphenol A 80-05-7 C15H16O2 793 suppliers $10.00-$1593.90
Bisphenol A 80-05-7 C15H16O2 793 suppliers $10.00-$1593.90
Bisphenol A 80-05-7 C15H16O2 793 suppliers $10.00-$1593.90
2,2-Bis(p-hydroxyphenyl)propane 80-05-7 C15H16O2 - Inquiry
2,2-Bis(p-hydroxyphenyl)propane 80-05-7 C15H16O2 - Inquiry

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