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Chromium Picolinate Protects against Testicular Damage in STZ-Induced Diabetic Rats via Anti-Inflammation, Anti-Oxidation, Inhibiting Apoptosis, and Regulating the TGF-β1/Smad Pathway

Published:20 November 2023 DOI: 10.3390/molecules28227669 PMID: 38005391
Hongxing Zheng,?Yingjun Hu,?Mengli Shao,?Simin Chen,?Shanshan Qi

Abstract

Chromium picolinate (CP) is an organic compound that has long been used to treat diabetes. Our previous studies found CP could relieve diabetic nephropathy. Thus, we speculate that it might have a positive effect on diabetic testicular injury. In this study, a diabetic rat model was established, and then the rats were treated with CP for 8 weeks. We found that the levels of blood glucose, food, and water intake were reduced, and body weight was enhanced in diabetic rats after CP supplementation. Meanwhile, in CP treatment groups, the levels of male hormone and sperm parameters were improved, the pathological structure of the testicular tissue was repaired, and testicular fibrosis was inhibited. In addition, CP reduced the levels of serum inflammatory cytokines, and decreased oxidative stress and apoptosis in the testicular tissue. In conclusion, CP could ameliorate testicular damage in diabetic rats, as well as being a potential testicle-protective nutrient in the future to prevent the testicular damage caused by diabetes.

Substances (10)

Materials
Procduct Name CAS Molecular Formula Supplier Price
Chromium picolinate 14639-25-9 C18H12CrN3O6 710 suppliers $5.00-$1398.40
Chromium picolinate 14639-25-9 C18H12CrN3O6 710 suppliers $5.00-$1398.40
Chromium picolinate 14639-25-9 C18H12CrN3O6 710 suppliers $5.00-$1398.40
Chromium picolinate 14639-25-9 C18H12CrN3O6 710 suppliers $5.00-$1398.40
Chromium(III) picolinate 14639-25-9 - Inquiry
Chromium(III) picolinate 14639-25-9 - Inquiry
Chromium(III) picolinate 14639-25-9 - Inquiry
Chromium(III) picolinate 14639-25-9 - Inquiry
Chromium picolinate 14639-25-9 - Inquiry
Chromium picolinate 14639-25-9 - Inquiry
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