一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

ChemicalBook >> journal list >> Molecules >>article
Molecules

Molecules

IF: 4.2
Download PDF

Solubility and Thermodynamics Data of Cabozantinib Malate in Various Aqueous Solutions of Dimethyl Sulfoxide at Different Temperatures.

Published:27 November 2023 DOI: 10.3390/molecules28237805 PMID: 38067534
Faiyaz Shakeel,?Nazrul Haq,?Sultan Alshehri,?Ibrahim A Alsarra

Abstract

Cabozantinib malate (CBZM), a new anticancer medication, has been studied for its solubility and thermodynamic properties in a variety of {dimethyl sulfoxide (DMSO) + water (H2O)} mixtures at 298.2-318.2 K and 101.1 kPa. Using the shake flask technique, the solubility of CBZM was assessed and the results were correlated to the van't Hoff, Apelblat, Buchowski-Ksiazczak λh, Yalkowsky-Roseman, Jouyban-Acree, and Jouyban-Acree-van't Hoff models. There was a significant correlation between the experimental CBZM solubility data and all computational models, as evidenced by the error values for all computational models being less than 5.0%. Temperature and DMSO mass percentage improved the CBZM mole fraction solubility in the cosolvent solutions of {DMSO + H2O}. At 318.2 K, pure DMSO had the highest mole fraction solubility of CBZM (4.38 × 10-2), whereas pure H2O had the lowest mole fraction solubility (2.24 × 10-7 at 298.2 K). The positive values of computed thermodynamic parameters indicated that the dissolution of CBZM was endothermic and entropy-driven in all of the {DMSO + H2O} solutions investigated. It was found that the CBZM solvation in {DMSO + H2O} solutions is governed by enthalpy. When compared to CBZM-H2O, CBZM-DMSO showed the highest molecular interactions. The findings of this investigation demonstrated that DMSO has a great deal of potential for CBZM solubilization in H2O.

Substances (4)

Related products
Procduct Name CAS Molecular Formula Supplier Price
Dimethyl sulfoxide 67-68-5 C2H6OS 1940 suppliers $5.00-$120900.00
Water 7732-18-5 H2O 775 suppliers $13.50-$6397.55
2-Methoxyethanol 109-86-4 C3H8O2 640 suppliers $7.62-$7070.00
Cabozantinib Malate 1140909-48-3 C32H30FN3O10 401 suppliers Inquiry

Similar articles

IF:2

Determination of the Solubility of Ammonium Dihydrogen Phosphate in Water–Ethanol System at Different Temperatures from 283.2 to 343.2 K

Journal of Chemical & Engineering Data Dejun Xu, Xing Xiong,etc Published: 7 December 2015
IF:2.3

Cryoprotection by dimethyl sulfoxide and dimethyl sulfone

Cryobiology Locksley E. McGann, Michele L. Walterson,etc Published: 1 February 1987
克山县| 张家口市| 商水县| 蒙山县| 富锦市| 忻城县| 酉阳| 山西省| 策勒县| 磐安县| 洪洞县| 横峰县| 大英县| 商水县| 顺义区| 临夏县| 昌都县| 石景山区| 怀来县| 普安县| 宁国市| 罗源县| 康保县| 项城市| 新巴尔虎右旗| 鱼台县| 吉安县| 陕西省| 巴东县| 赤壁市| 平谷区| 石城县| 定西市| 临城县| 即墨市| 宜宾县| 玉屏| 辉县市| 惠水县| 康平县| 房山区|