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The Journal of Organic Chemistry

The Journal of Organic Chemistry

IF: 3.3
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Dipeniroqueforins A–B and Peniroqueforin D: Eremophilane-Type Sesquiterpenoid Derivatives with Cytotoxic Activity from Penicillium roqueforti

Published:8 January 2024 DOI: 10.1021/acs.joc.3c02360
Shuyuan Mo, Yaxin Zhang, Rui Jiang, Hanxiao Zeng, Zhihong Huang, Jie Yin, Sitian Zhang, Jun Yao, Jianping Wang*, Zhengxi Hu* and Yonghui Zhang*, 

Abstract

Guided by the Global Natural Products Social (GNPS) molecular networking strategy, five undescribed eremophilane-type sesquiterpenoid derivatives (15) were isolated and identified from fungus Penicillium roqueforti, which was separated from the root soil of plant Hypericum beanii collected in Shennongjia Forestry District, Hubei Province. Dipeniroqueforins A–B (12), representing a lactam-type sesquiterpenoid skeleton with a highly symmetrical and homodimeric 5/6/6–6/6/5 hexacyclic system, are reported within the eremophilane-type family for the first time. Peniroqueforin D (5) represents the first example of a 1,2-seco eremophilane-type sesquiterpenoid derivative featuring an undescribed 7/6-fused ring system. The structures of these compounds were elucidated by various spectroscopic analyses, DP4+ probability analyses, ECD calculations, and single-crystal X-ray diffraction experiments. Furthermore, these isolates were evaluated for cytotoxicity, and the result uncovered that compound 1 displayed broad-spectrum activity. Further mechanistic study revealed that compound 1 could significantly upregulate the mRNA expression of genes related to the oxidative induction, leading to the abnormal ROS levels in tumor cells and ultimately causing tumor cell apoptosis.

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