一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

ChemicalBook >> journal list >> Neoplasia >>article
Neoplasia

Neoplasia

IF: 7.7
Download PDF

DNA methylation landscape reveals GNAS as a decitabine-responsive marker in patients with acute myeloid leukemia

Published:20 January 2024 DOI: 10.1016/j.neo.2024.100965
Shujiao He , Yan Li , Lei Wang , Yisheng Li , Lu Xu , Diya Cai , Jingfeng Zhou , Li Yu

Abstract

Background

The demethylation agent decitabine (DAC) is a pivotal non-intensive alternative treatment for acute myeloid leukemia (AML). However, patient responses to DAC are highly variable, and predictive biomarkers are warranted. Herein, the DNA methylation landscape of patients treated with a DAC-based combination regimen was compared with that of patients treated with standard chemotherapy to develop a molecular approach for predicting clinical response to DAC.

Methods

Twenty-five non-M3 AML patients were enrolled and subjected to DNA methylation sequencing and profiling to identify differentially methylated regions (DMRs) and genes of interest. Moreover, the effects of a DAC-based regimen on apoptosis and gene expression were explored using Kasumi-1 and K562 cells.

Results

Overall, we identified 541 DMRs that were specifically responsive to DAC, among which 172 DMRs showed hypomethylation patterns upon treatment and were aligned with the promoter regions of 182 genes. In particular, GNAS was identified as a critical DAC-responsive gene, with in vitro GNAS downregulation leading to reduced cell apoptosis induced by DAC and cytarabine combo treatment.

Conclusions

We found that GNAS is a DAC-sensitive gene in AML and may serve as a prognostic biomarker to assess the responsiveness of patients with AML to DAC-based therapy.

Substances (14)

Materials
Procduct Name CAS Molecular Formula Supplier Price
Cytarabine 147-94-4 C9H13N3O5 802 suppliers $5.00-$3650.00
Cytarabine 147-94-4 C9H13N3O5 802 suppliers $5.00-$3650.00
Cytarabine 147-94-4 C9H13N3O5 802 suppliers $5.00-$3650.00
Cytarabine 147-94-4 C9H13N3O5 802 suppliers $5.00-$3650.00
5-Aza-2'-deoxycytidine 2353-33-5 C8H12N4O4 748 suppliers $8.00-$2480.00
5-Aza-2'-deoxycytidine 2353-33-5 C8H12N4O4 748 suppliers $8.00-$2480.00
5-Aza-2'-deoxycytidine 2353-33-5 C8H12N4O4 748 suppliers $8.00-$2480.00
5-Aza-2'-deoxycytidine 2353-33-5 C8H12N4O4 748 suppliers $8.00-$2480.00
5-Aza-2'-deoxycytidine 2353-33-5 C8H12N4O4 - Inquiry
5-Aza-2'-deoxycytidine 2353-33-5 C8H12N4O4 - Inquiry

Similar articles

IF:1.2

Successful hyaluronic acid filler injection in a chronic myeloid leukemia patient taking imatinib mesylate.

Journal of Cosmetic and Laser Therapy Yegyu Sung, Min Hee Kim,etc Published: 1 January 2019
大渡口区| 沿河| 乌审旗| 定结县| 方城县| 武强县| 如皋市| 泰州市| 广平县| 昆山市| 宜兴市| 定襄县| 西乡县| 布尔津县| 合作市| 崇文区| 博乐市| 大安市| 贡嘎县| 沅陵县| 汤阴县| 温州市| 榆林市| 衡水市| 阳江市| 辽宁省| 鸡东县| 延津县| 色达县| 婺源县| 高雄县| 石嘴山市| 紫阳县| 宁安市| 乐至县| 应用必备| 永善县| 明水县| 汪清县| 综艺| 延川县|