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Neoplasia

Neoplasia

IF: 7.7
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WDR68 stimulates cellular proliferation via activating ribosome biogenesis in 293T cells

Published:26 July 2024 DOI: 10.1016/j.neo.2024.101033 PMID: 39067242
Zhaoxia Wu , Lanfeng Xie , Ping Yuan , Yimin Chu , Haixia Peng

Abstract

WDR68, a conserved WD40 repeat-containing protein, interacts with E1A and is involved in the E1A-induced cell proliferation and oncogenic transformation, but the intrinsic molecular mechanisms of this process remain to be elucidated. Here, we demonstrate that WDR68 promotes the proliferation of 293T cells by interacting with a series of ribosome biogenesis-regulating proteins. Gene Set Enrichment Analysis (GSEA) of RNA-seq data also revealed that the ribosome biogenesis-associated gene signatures could be the most significantly enriched in the WDR68 expression groups. In accordance, 293T cells are more sensitive to the ribosome biogenesis inhibitors than 293 cells. Taken together, our results indicated that WDR68 could promote cell proliferation through the activation of ribosome biogenesis in the 293T cell context. This provides new insights into the understanding of the function of WDR68 and the molecular characterisation of 293T tool cells.

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Materials
Procduct Name CAS Molecular Formula Supplier Price
CX-5461 1138549-36-6 C27H27N7O2S 176 suppliers $14.00-$2900.00
CX-5461 1138549-36-6 C27H27N7O2S 176 suppliers $14.00-$2900.00
CX-5461 1138549-36-6 C27H27N7O2S 176 suppliers $14.00-$2900.00
CX-5461 1138549-36-6 C27H27N7O2S 176 suppliers $14.00-$2900.00

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