一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

ChemicalBook >> journal list >> Journal of Antimicrobial Chemotherapy >>article
Journal of Antimicrobial Chemotherapy

Journal of Antimicrobial Chemotherapy

IF: 3.9
Download PDF

Repurposing cinacalcet suppresses multidrug-resistant Staphylococcus aureus by disruption of cell membrane and inhibits biofilm by targeting IcaR

Published:2 April 2024 DOI: 10.1093/jac/dkae051 PMID: 38412335
Zu-Ye Fang,?Zi-Yuan Zhang,?Yun-Dan Zheng,?Dan Lei,?Jianpeng Zhuang,?Nan Li,?Qing-Yu He,?Xuesong Sun

Abstract

Background: MDR Staphylococcus aureus infections, along with the severity of biofilm-associated infections, continue to threaten human health to a great extent. It necessitates the urgent development of novel antimicrobial and antibiofilm agents.

Objectives: To reveal the mechanism and target of cinacalcet as an antibacterial and antimicrobial agent for S. aureus.

Methods: Screening of non-antibiotic drugs for antibacterial and antibiofilm properties was conducted using a small-molecule drug library. In vivo efficacy was assessed through animal models, and the antibacterial mechanism was studied using quantitative proteomics, biochemical assays, LiP-SMap, BLI detection and gene knockout techniques.

Results: Cinacalcet, an FDA-approved drug, demonstrated antibacterial and antibiofilm activity against S. aureus, with less observed development of bacterial resistance. Importantly, cinacalcet significantly improved survival in a pneumonia model and bacterial clearance in a biofilm infection model. Moreover, the antibacterial mechanism of cinacalcet mainly involves the destruction of membrane-targeted structures, alteration of energy metabolism, and production of reactive oxygen species (ROS). Cinacalcet was found to target IcaR, inhibiting biofilm formation through the negative regulation of IcaADBC.

Conclusions: The findings suggest that cinacalcet has potential for repurposing as a therapeutic agent for MDR S. aureus infections and associated biofilms, warranting further investigation.

Similar articles

IF:0

Bioactivity of Mupirocin Nanoparticle-Loaded Hydrogel against Methicillin-Resistant Staphylococcus aureus (MRSA)

Applied microbiology Sukanjana Kamlungmak,?Monwadee Wonglapsuwan,etc Published: 3 March 2022
固始县| 军事| 宝丰县| 洮南市| 特克斯县| 澄江县| 南昌市| 华池县| 石景山区| 凉城县| 河北省| 普定县| 精河县| 武定县| 池州市| 通榆县| 青川县| 武邑县| 湖南省| 邹平县| 北海市| 抚宁县| 柳河县| 宜春市| 焉耆| 襄垣县| 兴化市| 青河县| 林西县| 青阳县| 宾川县| 米脂县| 武胜县| 通山县| 镇坪县| 交城县| 鹿泉市| 台中市| 龙山县| 巴东县| 昭觉县|