一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

ChemicalBook >> journal list >> Journal of Antimicrobial Chemotherapy >>article
Journal of Antimicrobial Chemotherapy

Journal of Antimicrobial Chemotherapy

IF: 3.9
Download PDF

A Phase 1 pharmacokinetic study of a single-dose bioadhesive clindamycin 2% gel for bacterial vaginosis.

Published:23 December 2022 DOI: 10.1093/jac/dkac386 PMID: 36418189
Christine K Mauck,?George J Atiee,?Jennifer McCulloh,?Laurie Reynolds,?Nadene Zack,?David R Friend

Abstract

Objectives: To evaluate pharmacokinetics (PK) of a single dose of an investigational 2% clindamycin phosphate vaginal gel in healthy women by assessment of plasma and vaginal clindamycin concentrations over 7?days, and assess safety.

Methods: Single-centre, Phase 1, single-dose PK study. Blood and vaginal samples were collected daily and safety was evaluated through to Day 7.

Results: Twenty-one subjects were enrolled; 20 completed the study. Plasma clindamycin concentrations demonstrated quantifiable values in all subjects through to 24?h post-dose, remaining above the limits of quantification (LOQ) through to 48?h for the majority of subjects. Systemic exposure (AUC0-t) was 1179 (range 62-3822)?h·ng/mL. Arithmetic mean AUC0-24 was 818 (range 51-3287)?h·ng/mL. Vaginal clindamycin phosphate levels were relatively high 24?h following administration in 15/21 subjects (6 subjects had values >400?μg/g and 9 had values of 100-400?μg/g). The levels dropped in most participants to below the LOQ 2?days following dosing. In a few participants, levels remained elevated for several days. Maximal amounts of vaginal clindamycin occurred on Day 2 with a mean value of 30.3?μg. One treatment-emergent adverse event (TEAE) of moderate-severity headache not related to study drug was reported and resolved on Day 1. No TEAEs were related to physical examinations, pelvic examinations, laboratory values or vital signs.

Conclusions: The vaginal concentrations of clindamycin phosphate plus the clindamycin plasma profile over time are consistent with release of drug from the investigational gel over 24 to 72?h. A single dose was well tolerated.

Substances (2)

Related products
Procduct Name CAS Molecular Formula Supplier Price
Clindamycin phosphate 24729-96-2 C18H34ClN2O8PS 632 suppliers $5.00-$2881.73
Clindamycin 18323-44-9 C18H33ClN2O5S 228 suppliers $15.00-$740.00

Similar articles

IF:0.4

Proof of concept study of a novel bioadhesive clindamycin phosphate 2% vaginal gel to treat bacterial vaginosis

Clinical and experimental obstetrics & gynecology A. Dupre,?H. Alur,etc Published: 14 August 2020
IF:2.4

Comparison of Clindamycin Phosphate Vaginal Cream With Triple Sulfonamide Vaginal Cream in the Treatment of Bacterial Vaginosis

Sexually transmitted diseases W. Mccormack,?Jean M. Covino,etc Published: 1 October 2001
IF:0

Single- and Multiple-Dose Pharmacokinetics of Dapoxetine Hydrochloride, a Novel Agent for the Treatment of Premature Ejaculation

The Journal of Clinical Pharmacology Nishit B. Modi PhD, Mark J. Dresser PhD,etc Published: 8 March 2013
南通市| 林西县| 会昌县| 壤塘县| 仁布县| 三台县| 江西省| 祁阳县| 铁岭市| 万山特区| 勐海县| 福鼎市| 米泉市| 来凤县| 镇原县| 阜宁县| 东兴市| 观塘区| 通榆县| 永顺县| 龙州县| 合江县| 昭通市| 江达县| 伊金霍洛旗| 织金县| 景洪市| 元谋县| 大悟县| 溧水县| 四子王旗| 大洼县| 绥化市| 呼和浩特市| 新乡县| 岳西县| 交口县| 汉阴县| 花垣县| 南平市| 治多县|