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Chemistry & Biodiversity

Chemistry & Biodiversity

IF: 2.5
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Chemical Constituents of Ajuga Lupulina and their Anti-Ferroptosis Activity

Published:1 March 2024 DOI: 10.1002/cbdv.202400244 PMID: 38426640
Xifeng Teng, Huiwen Shi, Liudan Cao, Xing Peng, Lin He, Qiong Gu

Abstract

Five new compounds (1, 2, 7, 12, and 16), along with fifteen known ones, were isolated from Ajuga lupulina Maxim. Their structures were revealed by analysing spectroscopic data (MS, NMR), and experimental and calculated ECD spectra was used to deduce the absolute configuration. Compound 16, with eight carbon atoms, was firstly isolated from the nature. All the isolates were evaluated for their inhibitory effect on RSL3-induced ferroptosis in HT22 mouse hippocampal neuronal cells. Among them, the abietane-type diterpenoids (711) significantly inhibited ferroptosis with EC50 values of 0.83?μM, 2.05?μM, 0.96?μM, 1.47?μM, and 1.19?μM, respectively.

Substances (8)

Materials
Procduct Name CAS Molecular Formula Supplier Price
Ferrostatin-1 (Fer-1) 347174-05-4 C15H22N2O2 248 suppliers $10.00-$2822.00
Ferrostatin-1 (Fer-1) 347174-05-4 C15H22N2O2 248 suppliers $10.00-$2822.00
Ferrostatin-1 (Fer-1) 347174-05-4 C15H22N2O2 248 suppliers $10.00-$2822.00
Ferrostatin-1 (Fer-1) 347174-05-4 C15H22N2O2 248 suppliers $10.00-$2822.00
RSL3 1219810-16-8 C23H21ClN2O5 218 suppliers $13.00-$2492.00
RSL3 1219810-16-8 C23H21ClN2O5 218 suppliers $13.00-$2492.00
RSL3 1219810-16-8 C23H21ClN2O5 218 suppliers $13.00-$2492.00
RSL3 1219810-16-8 C23H21ClN2O5 218 suppliers $13.00-$2492.00

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