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MedComm

IF: 10.7
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Maresin-1 ameliorates hypertensive vascular remodeling through its receptor LGR6

Published:9 March 2024 DOI:
Zheng Yin, Jishou Zhang, Mengmeng Zhao, Shanshan Peng, Jing Ye, Jianfang Liu, Yao Xu, Shuwan Xu, Wei Pan, Cheng Wei, Juan-Juan Qin, Jun Wan, Menglong Wang

Abstract

Hypertensive vascular remodeling is defined as the changes in vascular function and structure induced by persistent hypertension. Maresin-1 (MaR1), one of metabolites from Omega-3 fatty acids, has been reported to promote inflammation resolution in several inflammatory diseases. This study aims to investigate the effect of MaR1 on hypertensive vascular remodeling. Here, we found serum MaR1 levels were reduced in hypertensive patients and was negatively correlated with systolic blood pressure (SBP). The treatment of MaR1 reduced the elevation of blood pressure and alleviated vascular remodeling in the angiotensin II (AngII)-infused mouse model. In addition, MaR1-treated vascular smooth muscle cells (VSMCs) exhibited reduced excessive proliferation, migration, and phenotype switching, as well as impaired pyroptosis. However, the knockout of the receptor of MaR1, leucine-rich repeat-containing G protein-coupled receptor 6 (LGR6), was seen to aggravate pathological vascular remodeling, which could not be reversed by additional MaR1 treatment. The mechanisms by which MaR1 regulates vascular remodeling through LGR6 involves the Ca2+/calmodulin-dependent protein kinase II/nuclear factor erythroid 2-related factor 2/heme oxygenase-1 signaling pathway. Overall, supplementing MaR1 may be a novel therapeutic strategy for the prevention and treatment of hypertension.

Substances (8)

Materials
Procduct Name CAS Molecular Formula Supplier Price
KN-93 139298-40-1 C26H29ClN2O4S 201 suppliers $25.00-$5300.00
KN-93 139298-40-1 C26H29ClN2O4S 201 suppliers $25.00-$5300.00
KN-93 139298-40-1 C26H29ClN2O4S 201 suppliers $25.00-$5300.00
KN-93 139298-40-1 C26H29ClN2O4S 201 suppliers $25.00-$5300.00
ML385 846557-71-9 C29H25N3O4S 155 suppliers $18.00-$2646.00
ML385 846557-71-9 C29H25N3O4S 155 suppliers $18.00-$2646.00
ML385 846557-71-9 C29H25N3O4S 155 suppliers $18.00-$2646.00
ML385 846557-71-9 C29H25N3O4S 155 suppliers $18.00-$2646.00

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