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Cell Death and Differentiation

Cell Death and Differentiation

IF: 15.4
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Proteinase 3 depletion attenuates leukemia by promoting myeloid differentiation

Published:8 April 2024 DOI: 10.1038/s41418-024-01288-4
Huan Liu, Lu Sun, Hongfei Zhao, Zihan Zhao, Shiyue Zhang, Shan Jiang, Tianran Cheng, Xiaohan Wang, Tong Wang, Ya Shao, Haiyan Zhu, Huijuan Han, Yigeng Cao, Erlie Jiang, Yihai Cao, Yuanfu Xu

Abstract

Hematopoietic stem and progenitor cells (HSPCs) that have impaired differentiation can transform into leukemic blasts. However, the mechanism that controls differentiation remains elusive. Here, we show that the genetic elimination of Proteinase 3 (PRTN3) in mice led to spontaneous myeloid differentiation. Mechanistically, our findings indicate that PRTN3 interacts with the N-terminal of STAT3, serving as a negative regulator of STAT3-dependent myeloid differentiation. Specifically, PRTN3 promotes STAT3 ubiquitination and degradation, while simultaneously reducing STAT3 phosphorylation and nuclear translocation during G-CSF-stimulated myeloid differentiation. Strikingly, pharmacological inhibition of STAT3 (Stattic) partially counteracted the effects of PRTN3 deficiency on myeloid differentiation. Moreover, the deficiency of PRTN3 in primary AML blasts promotes the differentiation of those cells into functional neutrophils capable of chemotaxis and phagocytosis, ultimately resulting in improved overall survival rates for recipients. These findings indicate PRTN3 exerts an inhibitory effect on STAT3-dependent myeloid differentiation and could be a promising therapeutic target for the treatment of acute myeloid leukemia.

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