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FEBS Open Bio

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HELQ deficiency impairs the induction of primordial germ cell-like cells

Published:8 May 2024 DOI: 10.1002/2211-5463.13810 PMID: 38720471
Cong Wan, Yaping Huang, Xingguo Xue, Gang Chang, Mei Wang, Xiao-Yang Zhao, Fang Luo, Zhi-Zhong Tang

Abstract

Helicase POLQ-like (HELQ) is a DNA helicase essential for the maintenance of genome stability. A recent study identified two HELQ missense mutations in some cases of infertile men. However, the functions of HELQ in the process of germline specification are not well known and whether its function is conserved between mouse and human remains unclear. Here, we revealed that Helq knockout (Helq?/?) could significantly reduce the efficiency of mouse primordial germ cell-like cell (PGCLC) induction. In addition, Helq?/? embryonic bodies exhibited a severe apoptotic phenotype on day 6 of mouse PGCLC induction. p53 inhibitor treatment could partially rescue the generation of mouse PGCLCs from Helq mutant mouse embryonic stem cells. Finally, the genetic ablation of HELQ could also significantly impede the induction of human PGCLCs. Collectively, our study sheds light on the involvement of HELQ in the induction of both mouse and human PGCLCs, providing new insights into the mechanisms underlying germline differentiation and the genetic studies of human fertility.

Substances (8)

Materials
Procduct Name CAS Molecular Formula Supplier Price
CHIR-99021 252917-06-9 C22H18Cl2N8 340 suppliers $28.00-$4401.00
CHIR-99021 252917-06-9 C22H18Cl2N8 340 suppliers $28.00-$4401.00
CHIR-99021 252917-06-9 C22H18Cl2N8 340 suppliers $28.00-$4401.00
CHIR-99021 252917-06-9 C22H18Cl2N8 340 suppliers $28.00-$4401.00
PD 0325901 391210-10-9 C16H14F3IN2O4 281 suppliers $8.00-$3990.00
PD 0325901 391210-10-9 C16H14F3IN2O4 281 suppliers $8.00-$3990.00
PD 0325901 391210-10-9 C16H14F3IN2O4 281 suppliers $8.00-$3990.00
PD 0325901 391210-10-9 C16H14F3IN2O4 281 suppliers $8.00-$3990.00

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