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Journal of Genetics and Genomics

Journal of Genetics and Genomics

IF: 6.6
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Znf706 regulates germ plasm assembly and primordial germ cell development in zebrafish

Published:19 November 2024 DOI: 10.1016/j.jgg.2024.11.007 PMID: 39571790
Weiying Zhang, Yaqi Li, Xiaotong Wu

Abstract

The cell fate of primordial germ cells (PGCs) in zebrafish is pre-determined by maternally deposited germ plasm, which is packaged into ribonucleoprotein complex in oocytes and inherited into PGCs-fated cells in embryos. However, the maternal factors regulating the assembly of germ plasm and PGC development remain poorly understood. In this study, we report that the maternal transcription factor Znf706 regulates the assembly of germ plasm factors into a granule-like structure localized perinuclearly in PGCs during migration. Maternal and zygotic mutants of znf706 (MZznf706) exhibit deficient germ plasm scattering at the early embryonic stage, decreased PGC numbers with some mislocation during PGC migration, and a lower female ratio in adulthood. Notably, the implementation of Znf706 CUT&Tag and RNA-seq on immature oocytes uncovers that Znf706 in stage I oocytes may promote transcription of several mitochondrial genes in addition to other functions. Hence, we propose that Znf706 is implicated in germ plasm assembly and PGC development in zebrafish.

Substances (2)

Materials
Procduct Name CAS Molecular Formula Supplier Price
Deoxyribonuclease 9003-98-9 NULL 644 suppliers $52.00-$2400.00
4',6-Diamidino-2-phenylindole dihydrochloride 28718-90-3 C16H16ClN5 610 suppliers $15.00-$4800.00

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