一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

ChemicalBook >> journal list >> Journal of Genetics and Genomics >>article
Journal of Genetics and Genomics

Journal of Genetics and Genomics

IF: 6.6
Download PDF

Znf706 regulates germ plasm assembly and primordial germ cell development in zebrafish

Published:19 November 2024 DOI: 10.1016/j.jgg.2024.11.007 PMID: 39571790
Weiying Zhang, Yaqi Li, Xiaotong Wu

Abstract

The cell fate of primordial germ cells (PGCs) in zebrafish is pre-determined by maternally deposited germ plasm, which is packaged into ribonucleoprotein complex in oocytes and inherited into PGCs-fated cells in embryos. However, the maternal factors regulating the assembly of germ plasm and PGC development remain poorly understood. In this study, we report that the maternal transcription factor Znf706 regulates the assembly of germ plasm factors into a granule-like structure localized perinuclearly in PGCs during migration. Maternal and zygotic mutants of znf706 (MZznf706) exhibit deficient germ plasm scattering at the early embryonic stage, decreased PGC numbers with some mislocation during PGC migration, and a lower female ratio in adulthood. Notably, the implementation of Znf706 CUT&Tag and RNA-seq on immature oocytes uncovers that Znf706 in stage I oocytes may promote transcription of several mitochondrial genes in addition to other functions. Hence, we propose that Znf706 is implicated in germ plasm assembly and PGC development in zebrafish.

Substances (2)

Materials
Procduct Name CAS Molecular Formula Supplier Price
Deoxyribonuclease 9003-98-9 NULL 644 suppliers $52.00-$2400.00
4',6-Diamidino-2-phenylindole dihydrochloride 28718-90-3 C16H16ClN5 610 suppliers $15.00-$4800.00

Similar articles

IF:4.9

Diflubenzuron Induces Cardiotoxicity in Zebrafish Embryos.

International Journal of Molecular Sciences Xue Han,?Xiaowen Xu,etc Published: 8 October 2022
IF:14.3

ZFP36 Regulates Vascular Smooth Muscle Contraction and Maintains Blood Pressure

Advanced Science Xiuru Cui, Yawei Wang,etc Published: 26 November 2024
遂川县| 民权县| 华容县| 得荣县| 安阳市| 神农架林区| 临朐县| 宝坻区| 龙陵县| 建昌县| 定日县| 贵溪市| 佛山市| 北辰区| 霸州市| 许昌市| 永胜县| 马关县| 清徐县| 泰来县| 乌兰浩特市| 新龙县| 普安县| 榆中县| 泊头市| 米脂县| 宕昌县| 砚山县| 望江县| 阿勒泰市| 东平县| 梧州市| 即墨市| 荔浦县| 宾阳县| 侯马市| 保靖县| 托克逊县| 商水县| 石景山区| 宁陵县|