一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

ChemicalBook >> journal list >> Advanced Science >>article
Advanced Science

Advanced Science

IF: 14.3
Download PDF

ZFP36 Regulates Vascular Smooth Muscle Contraction and Maintains Blood Pressure

Published:26 November 2024 DOI: 10.1002/advs.202408811 PMID: 39589932
Xiuru Cui, Yawei Wang, Hanlin Lu, Lei Wang, Xianwei Xie, Shenghao Zhang, Pavel Kovarik, Shuijie Li, Shanshan Liu, Qunye Zhang, Jianmin Yang, Cheng Zhang, Jinwei Tian, Yan Liu, Wencheng Zhang

Abstract

Hypertension remains a major risk factor for cardiovascular diseases, but the underlying mechanisms are not well understood. Zinc finger protein 36 (ZFP36) is an RNA-binding protein that regulates mRNA stability by binding to adenylate-uridylate-rich elements in the mRNA 3'-untranslated region. This study reveals that ZFP36 expression is highly elevated in the arteries of hypertensive patients and rodents. In cultured vascular smooth muscle cell (VSMC), angiotensin II (AngII) activates poly (ADP-ribose) polymerases1 (PARP1) to stimulate Zfp36 expression at the transcriptional level. VSMC-specific ZFP36 deletion reduces vessel contractility and blood pressure levels in mice. Mechanistically, ZFP36 regulates G protein-coupled receptors (GPCRs)-mediated increases in intracellular calcium levels through impairing the mRNA stability of regulator of G protein signaling 2 (RGS2). Moreover, the VSMC-specific ZFP36 deficiency attenuates AngII-induced hypertension and vascular remodeling in mice. AAV-mediated ZFP36 knockdown ameliorates spontaneous hypertension in rats. These findings elucidate that ZFP36 plays an important role in the regulation of smooth muscle contraction and blood pressure through modulating RGS2 expression. ZFP36 inhibition may represent a new therapeutic strategy for the treatment of hypertension.

Substances (1)

Materials
Procduct Name CAS Molecular Formula Supplier Price
Elastase 39445-21-1 NULL 253 suppliers $48.00-$2350.00

Similar articles

IF:5

Effect of magnesium chloride on rabbit bronchial smooth muscle.

Annals of emergency medicine W H Spivey, E M Skobeloff,etc Published: 1 October 1990
IF:4.6

Intraocular and intracranial pressure in glaucoma patients taking acetazolamide.

ACS Applied Bio Materials Allison R Loiselle, Emile de Kleine,etc Published: 18 June 2020
IF:6.6

Znf706 regulates germ plasm assembly and primordial germ cell development in zebrafish

Journal of Genetics and Genomics Weiying Zhang, Yaqi Li,etc Published: 19 November 2024
百色市| 凤翔县| 昌邑市| 安新县| 安乡县| 禄丰县| 犍为县| 分宜县| 巴彦淖尔市| 北碚区| 玉山县| 康保县| 恭城| 崇文区| 开远市| 开鲁县| 河池市| 台南市| 信阳市| 建平县| 仙桃市| 延安市| 克什克腾旗| 海林市| 乐山市| 泰和县| 高州市| 花垣县| 山阳县| 肥东县| 长宁区| 宜丰县| 安龙县| 广元市| 隆安县| 彭水| 铅山县| 昭觉县| 天峨县| 临洮县| 云阳县|