一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

ChemicalBook >> journal list >> FEBS Letters >>article
FEBS Letters

FEBS Letters

IF: 3
Download PDF

Serine 3.39 and isoleucine 4.60 are key sites for 5-HT2AR-mediated Gs signaling

Published:16 May 2024 DOI: 10.1002/1873-3468.14904 PMID: 38757247
Lulu Xie, Xiaoqian Liu, Yishan Yao, Bo Tan, Ruibin Su

Abstract

Certain amino acid sites of 5-HT2AR play crucial roles in interacting with various G proteins. Hallucinogens and non-hallucinogens both act on 5-HT2AR but mediate different pharmacological effects, possibly due to the coupling of different G proteins. Therefore, this study identified the binding sites of hallucinogens and non-hallucinogens with 5-HT2AR through molecular docking. We conducted site mutation to examine the impact of these sites on G proteins, in order to find out the sites that can distinguish the pharmacological effects of hallucinogens and non-hallucinogens. Our results indicate that I4.60A and S3.39A did not affect the ability of hallucinogens to activate Gq signaling, but significantly reduced Gs signaling activation by hallucinogens. These results suggest that S3.39 and I4.60 are important for the activation of Gs signaling by hallucinogens.

Substances (4)

Materials
Procduct Name CAS Molecular Formula Supplier Price
Azepino[4,5-b]indole, 1,2,3,4,5,6-hexahydro-8-methoxy-3-methyl- 2483829-58-7 C14H18N2O 26 suppliers Inquiry
Azepino[4,5-b]indole, 1,2,3,4,5,6-hexahydro-8-methoxy-3-methyl- 2483829-58-7 C14H18N2O 26 suppliers Inquiry
Azepino[4,5-b]indole, 1,2,3,4,5,6-hexahydro-8-methoxy-3-methyl- 2483829-58-7 C14H18N2O 26 suppliers Inquiry
Azepino[4,5-b]indole, 1,2,3,4,5,6-hexahydro-8-methoxy-3-methyl- 2483829-58-7 C14H18N2O 26 suppliers Inquiry

Similar articles

IF:2.9

Abstract 6608: Therapeutic enzyme depletion of L-serine for the treatment of serine auxotrophic tumors

ACS Chemical Health & Safety Vipin Rawat, Huiping Zhao,etc Published: 22 March 2024
IF:3.3

Andrographolide and its derivatives are effective compounds for gastrointestinal protection: a review.

European review for medical and pharmacological sciences D-W Wang, Y-J Xiang,etc Published: 1 March 2021
IF:4.5

Antimicrobial agent chloroxylenol targets β?catenin?mediated Wnt signaling and exerts anticancer activity in colorectal cancer.

International journal of oncology Qi Sun, Boxin Liu,etc Published: 1 November 2023
衡南县| 舟曲县| 涞源县| 西盟| 凤城市| 安化县| 武乡县| 涟水县| 保亭| 丰宁| 会宁县| 南部县| 剑阁县| 新安县| 车险| 双峰县| 清水河县| 崇义县| 洪洞县| 平原县| 土默特左旗| 鲁甸县| 阜城县| 广汉市| 紫阳县| 南汇区| 隆德县| 新疆| 太保市| 鱼台县| 井研县| 扶风县| 芮城县| 汽车| 兴和县| 鄂托克前旗| 蒲江县| 平果县| 高要市| 寿宁县| 尉犁县|