一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

ChemicalBook >> journal list >> Cell reports >>article
Cell reports

Cell reports

IF: 7.5
Download PDF

Structural insights into ligand recognition and activation of the succinate receptor SUCNR1.

Published:23 July 2024 DOI: 10.1016/j.celrep.2024.114381 PMID: 38923454
Aijun Liu,?Yezhou Liu,?Weijia Zhang,?Richard D Ye

Abstract

Succinate, a citric acid cycle intermediate, serves important functions in energy homeostasis and metabolic regulation. Extracellular succinate acts as a stress signal through succinate receptor (SUCNR1), a class A G protein-coupled receptor. Research on succinate signaling is hampered by the lack of high-resolution structures of the agonist-bound receptor. We present cryoelectron microscopy (cryo-EM) structures of SUCNR1-Gi complexes bound to succinate and its non-metabolite derivative cis-epoxysuccinate. Key determinants for the recognition of succinate in cis conformation include R2817.39 and Y832.64, while Y301.39 and R993.29 participate in the binding of both succinate and cis-epoxysuccinate. Extracellular loop 2, through F175ECL2 in its β-hairpin, forms a hydrogen bond with succinate and caps the binding pocket. At the receptor-Gi interface, agonist binding induces the rearrangement of a hydrophobic network on transmembrane (TM)5 and TM6, leading to TM signaling through TM3 and TM7. These findings extend our understanding of succinate recognition by SUCNR1, aiding the development of therapeutics for the succinate receptor.

Similar articles

IF:3.2

β-Galactosidase: Immune recognition of conformation and mechanism of antibody-induced catalytic activation

Biopolymers Franco Celada, Roberto Strom,etc Published: 1 January 1983
IF:1.1

New Insights into the Mechanism of Reduction of Tertiary Phosphine Oxides by Means of Phenylsilane

Heteroatom Chemistry Oleg M. Demchuk, Radomir Jasiński,etc Published: 27 July 2015
旅游| 白玉县| 全椒县| 抚顺县| 保定市| 昌吉市| 咸宁市| 贵南县| 肥东县| 裕民县| 化德县| 即墨市| 佛坪县| 历史| 塔河县| 文登市| 商河县| 宿州市| 霞浦县| 甘洛县| 石城县| 淳安县| 德惠市| 班玛县| 象州县| 余干县| 循化| 东乡| 武定县| 临颍县| 印江| 大竹县| 河津市| 镇雄县| 巴东县| 邯郸市| 连州市| 寻甸| 图们市| 罗甸县| 莫力|