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Cell Discovery

Cell Discovery

IF: 12.5
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Pig blastocyst-like structure models from embryonic stem cells

Published:2 July 2024 DOI: 10.1038/s41421-024-00693-w PMID: 38956027
Jinzhu Xiang,?Hanning Wang,?Bingbo Shi,?Jiajun Li,?Dong Liu,?Kaipeng Wang,?Zhuangfei Wang,?Qiankun Min,?Chengchen Zhao,?Duanqing Pei

Abstract

Pluripotent stem cells have the potential to generate embryo models that can recapitulate developmental processes in vitro. Large animals such as pigs may also benefit from stem-cell-based embryo models for improving breeding. Here, we report the generation of blastoids from porcine embryonic stem cells (pESCs). We first develop a culture medium 4FIXY to derive pESCs. We develop a 3D two-step differentiation strategy to generate porcine blastoids from the pESCs. The resulting blastoids exhibit similar morphology, size, cell lineage composition, and single-cell transcriptome characteristics to blastocysts. These porcine blastoids survive and expand for more than two weeks in vitro under two different culture conditions. Large animal blastoids such as those derived from pESCs may enable in vitro modeling of early embryogenesis and improve livestock species' breeding practices.

Substances (4)

Materials
Procduct Name CAS Molecular Formula Supplier Price
Y27632 (hydrochloride) 129830-38-2 C14H23Cl2N3O 226 suppliers $23.00-$5472.00
Y27632 (hydrochloride) 129830-38-2 C14H23Cl2N3O 226 suppliers $23.00-$5472.00
Y27632 (hydrochloride) 129830-38-2 C14H23Cl2N3O 226 suppliers $23.00-$5472.00
Y27632 (hydrochloride) 129830-38-2 C14H23Cl2N3O 226 suppliers $23.00-$5472.00

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