一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

ChemicalBook >> journal list >> Cell reports >>article
Cell reports

Cell reports

IF: 7.5
Download PDF

Deubiquitylase OTUD3 regulates integrated stress response to suppress progression and sorafenib resistance of liver cancer.

Published:23 July 2024 DOI: 10.1016/j.celrep.2024.114487 PMID: 38996071
Hongmiao Dai,?Bo Wu,?Yingwei Ge,?Yang Hao,?Lijie Zhou,?Ruolin Hong,?Jinhao Zhang,?Wenli Jiang,?Yuting Zhang,?Hongchang Li,?Lingqiang Zhang

Abstract

The integrated stress response (ISR) is activated in response to intrinsic and extrinsic stimuli, playing a role in?tumor progression and drug resistance. The regulatory role and mechanism of ISR in liver cancer, however, remain largely unexplored. Here, we demonstrate that OTU domain-containing protein 3 (OTUD3) is a deubiquitylase of eukaryotic initiation factor 2α (eIF2α), antagonizing ISR and suppressing liver cancer. OTUD3 decreases interactions between eIF2α and the kinase EIF2ΑK3 by removing K27-linked polyubiquitylation on eIF2α. OTUD3 deficiency in mice leads to enhanced ISR and accelerated progression of N-nitrosodiethylamine-induced hepatocellular carcinoma. Additionally, decreased OTUD3 expression associated with elevated eIF2α phosphorylation correlates with the progression of human liver cancer. Moreover, ISR activation due to decreased OTUD3 expression renders liver cancer cells resistant to sorafenib, while the combined use of the ISR inhibitor ISRIB significantly improves their sensitivity to sorafenib. Collectively, these findings illuminate the regulatory mechanism of ISR in liver cancer and provide a potential strategy to counteract sorafenib resistance.

Substances (4)

Materials
Procduct Name CAS Molecular Formula Supplier Price
BTdCPU 1257423-87-2 C13H8Cl2N4OS 54 suppliers Inquiry
BTdCPU 1257423-87-2 C13H8Cl2N4OS 54 suppliers Inquiry
BTdCPU 1257423-87-2 C13H8Cl2N4OS 54 suppliers Inquiry
BTdCPU 1257423-87-2 C13H8Cl2N4OS 54 suppliers Inquiry

Similar articles

IF:0

Resistance to trimethoprim-sulfamethoxazole.

Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America G. Eliopoulos,?P. Huovinen,etc Published: 1 June 2001
沈阳市| 东乌珠穆沁旗| 丁青县| 辽源市| 应城市| 湖口县| 凯里市| 蒙阴县| 克拉玛依市| 梁山县| 红桥区| 建始县| 兴和县| 隆安县| 镇巴县| 砀山县| 礼泉县| 海安县| 龙岩市| 那曲县| 屯门区| 西宁市| 新闻| 乌兰浩特市| 禄劝| 上杭县| 星子县| 林甸县| 乌海市| 娄烦县| 奇台县| 弥勒县| 武陟县| 永济市| 鄯善县| 浠水县| 隆化县| 隆安县| 长春市| 元朗区| 六安市|