一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

ChemicalBook >> journal list >> Cell reports >>article
Cell reports

Cell reports

IF: 7.5
Download PDF

Tumor-intrinsic P2RY6 drives immunosuppression by enhancing PGE2 production

Published:23 July 2024 DOI: 10.1016/j.celrep.2024.114469 PMID: 38996067
Xilong Xu,?Yi Lu,?Longzhi Cao,?Yang Miao,?Yamei Li,?Yue Cui,?Ting Han

Abstract

Despite the success of anti-programmed cell death-1 (anti-PD-1) immunotherapy, many cancer patients remain unresponsive, and reliable predictive biomarkers are lacking. Here, we show that aberrant expression of the pyrimidinergic receptor P2RY6 is frequent in human cancers and causes immune evasion. In mouse syngeneic and human xenograft tumor models, ectopic expression of P2RY6 shapes an immunosuppressive tumor microenvironment (TME) to enhance tumor growth and resistance to immunotherapy, whereas deletion of P2RY6 from tumors with high P2RY6 expression inflames the TME to inhibit tumor growth. As a G protein-coupled receptor, P2RY6 activates Gq/phospholipase C-β signaling and stimulates the synthesis of prostaglandin E2, which is a key mediator of immunosuppression in the TME. In contrast to the essential role of P2RY6 in tumors, global deletion of P2ry6 from mice does not compromise viability. Our study thus?nominates P2RY6 as a precision immunotherapy target for patients with high tumor-intrinsic P2RY6 expression.

Substances (8)

Materials
Procduct Name CAS Molecular Formula Supplier Price
STAUROSPORINE 62996-74-1 C28H26N4O3 451 suppliers $10.00-$3200.00
STAUROSPORINE 62996-74-1 C28H26N4O3 451 suppliers $10.00-$3200.00
STAUROSPORINE 62996-74-1 C28H26N4O3 451 suppliers $10.00-$3200.00
STAUROSPORINE 62996-74-1 C28H26N4O3 451 suppliers $10.00-$3200.00
Uridine-5'-diphosphate disodium salt 27821-45-0 C9H15N2NaO12P2 395 suppliers $9.00-$1455.30
Uridine-5'-diphosphate disodium salt 27821-45-0 C9H15N2NaO12P2 395 suppliers $9.00-$1455.30
Uridine-5'-diphosphate disodium salt 27821-45-0 C9H15N2NaO12P2 395 suppliers $9.00-$1455.30
Uridine-5'-diphosphate disodium salt 27821-45-0 C9H15N2NaO12P2 395 suppliers $9.00-$1455.30

Similar articles

IF:5.2

n-Butanol production by Rhodopseudomonas palustris TIE-1

Communications Biology Wei Bai, Tahina Onina Ranaivoarisoa,etc Published: 3 November 2021
IF:0

ENHANCING THE SUNSCREEN EFFICACY OF BEMOTRIZINOL MICROPIGMENT BY USING O/W NANOEMULSION TOPICAL PREPARATIONS

International Journal of Pharmacy and Pharmaceutical Sciences Dina Hashim,?N. M. Sheta,etc Published: 17 May 2019
大安市| 喜德县| 金山区| 蓝山县| 诸城市| 大同市| 资溪县| 石家庄市| 民和| 鞍山市| 武隆县| 德令哈市| 县级市| 陆良县| 彰化县| 日照市| 桂东县| 德庆县| 昌宁县| 犍为县| 红原县| 施秉县| 恩平市| 双峰县| 永定县| 平顺县| 申扎县| 都昌县| 延津县| 库伦旗| 嵊州市| 紫云| 施甸县| 诸城市| 武功县| 景德镇市| 容城县| 蕉岭县| 玉门市| 辽阳县| 扎囊县|