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Journal of cellular biochemistry

Journal of cellular biochemistry

IF: 2.8
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Let?7f?5p Regulated by Hsa_circ_0000437 Ameliorates Bleomycin-Induced Skin Fibrosis

Published:14 July 2024 DOI: 10.1002/jcb.30629 PMID: 39004898
Baiting Liu, Chenxi Li, Yunyao Bo, Guiping Tian, Lijun Yang, Jianjun Si, Lin Zhang, Yuan Yan

Abstract

The current treatment of skin fibrosis is limited in its effectiveness due to a lack of understanding of the underlying mechanisms. Previous research has shown a connection between microRNAs (miRNAs) and the development of skin fibrosis. Therefore, investigating miRNA for the treatment of skin fibrotic diseases is highly important and merits further exploration. In this study, we have discovered that let-7f-5p could suppress the proliferation, migration, and expression of collagen type I alpha 1 (COL1A1) in human dermal fibroblasts (HDFs). It was further determined that let-7f-5p could target thrombospondin-1 (THBS1), thereby inhibiting the TGF-β2/Smad3 signaling pathway and exerting its biological effects. Additionally, let-7f-5p is regulated by Hsa_circ_0000437, which acts as a sponge molecule for let-7f-5p and consequently regulates the biological function of HDFs. Furthermore, our findings indicate that in vivo overexpression of let-7f-5p leads to a reduction in dermal thickness and COL1A1 expression, effectively inhibiting the progression of bleomycin (BLM)-induced skin fibrosis in mice. Hence, our research enhances the comprehension of the Hsa_circ_0000437/let-7f-5p/THBS1/TGF-β2/Smad3 regulatory network, highlighting the potential of let-7f-5p as a therapeutic approach for the treatment of skin fibrosis.

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Materials
Procduct Name CAS Molecular Formula Supplier Price
SB 431542 301836-41-9 C22H16N4O3 315 suppliers $30.00-$2822.00
SB 431542 301836-41-9 C22H16N4O3 315 suppliers $30.00-$2822.00
SB 431542 301836-41-9 C22H16N4O3 315 suppliers $30.00-$2822.00
SB 431542 301836-41-9 C22H16N4O3 315 suppliers $30.00-$2822.00
BLM-IN-1 2056014-40-3 C28H35FN4O 15 suppliers Inquiry
BLM-IN-1 2056014-40-3 C28H35FN4O 15 suppliers Inquiry
BLM-IN-1 2056014-40-3 C28H35FN4O 15 suppliers Inquiry
BLM-IN-1 2056014-40-3 C28H35FN4O 15 suppliers Inquiry
SB 431542 hydrate 301836-41-9 1 suppliers Inquiry
SB 431542 hydrate 301836-41-9 1 suppliers Inquiry

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