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Toxicology letters

Toxicology letters

IF: 2.9
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New metabolites of 2-ethylhexyl salicylate in human urine after simulated real-life dermal sunscreen application

Published:20 July 2024 DOI: 10.1016/j.toxlet.2024.07.912 PMID: 39034015
Laura Kuhlmann, Thomas G?en, Julia Hiller

Abstract

2-Ethylhexyl salicylate (EHS) is an organic UV filter which is used in sunscreen and other personal care products. The dermal uptake of EHS was studied in several dermal-exposure experiments. This paper aims to coherently assess urine samples after dermal exposure for the biomarkers EHS, 5OH-EHS, 5oxo-EHS, and 5cx-EPS as well as further biomarkers of interest, specifically 4OH-EHS, 4oxo-EHS, 2OH-EHS, and 6OH-EHS, for the first time. Samples from 18 participants of a pre-existing dermal exposure study under real-life conditions were reassessed using a comprehensive LC-MS/MS method. EHS accounts for 34?% of the cumulative excretion of all analytes within 24?h after exposure, followed by 5OH-EHS (19?%), 5cx-EPS (18?%), 4OH-EHS (15?%) and 5oxo-EHS (11?%). Further metabolites were only quantified in minor amounts. EHS as the most prominent excretion parameter in this study demonstrates the missing first-pass effect after dermal absorption. Furthermore, the applied novel comprehensive analytical procedure revealed oxidation at the ω (5cx-EPS, 6OH-EHS), ω-1 (5OH-EHS, 5oxo-EHS), and ω-2 positions (4OH-EHS, 4oxo-EHS) in the main chain of the ethylhexyl group as well as oxidation in the side chain (2OH-EHS). The presented data are of high relevance for a reliable toxicological risk assessment of dermal exposure to EHS.

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Procduct Name CAS Molecular Formula Supplier Price
2-Ethylhexyl salicylate 118-60-5 C15H22O3 521 suppliers $11.00-$6728.34
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