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Advanced Science

Advanced Science

IF: 14.3
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The Hemagglutinin of Influenza A Virus Induces Ferroptosis to Facilitate Viral Replication.

Published:19 August 2024 DOI: 10.1002/advs.202404365 PMID: 39159143
Aotian Ouyang, Tong Chen, Yi Feng, Jiahui Zou, Shaoyu Tu, Meijun Jiang, Huimin Sun, Hongbo Zhou

Abstract

Ferroptosis is a novel form of cell death caused by the accumulation of lipid peroxides in an iron-dependent manner. However, the precise mechanism underlying the exploitation of ferroptosis by influenza A viruses (IAV) remains unclear. The results demonstrate that IAV promotes its own replication through ferritinophagy by sensitizing cells to ferroptosis, with hemagglutinin identified as a key trigger in this process. Hemagglutinin interacts with autophagic receptors nuclear receptor coactivator 4 (NCOA4) and tax1-binding protein 1 (TAX1BP1), facilitating the formation of ferritin-NCOA4 condensates and inducing ferritinophagy. Further investigation shows that hemagglutinin-induced ferritinophagy causes cellular lipid peroxidation, inhibits aggregation of mitochondrial antiviral signaling protein (MAVS), and suppresses the type I interferon response, thereby contributing to viral replication. Collectively, a novel mechanism by which IAV hemagglutinin induces ferritinophagy resulting in cellular lipid peroxidation, consequently impairing MAVS-mediated antiviral immunity, is revealed.

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Materials
Procduct Name CAS Molecular Formula Supplier Price
HNE 75899-68-2 C9H16O2 149 suppliers $46.00-$2600.00
HNE 75899-68-2 C9H16O2 149 suppliers $46.00-$2600.00
HNE 75899-68-2 C9H16O2 149 suppliers $46.00-$2600.00
HNE 75899-68-2 C9H16O2 149 suppliers $46.00-$2600.00

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