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FASEB Journal

IF: 4.4
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Lycium barbarum polysaccharide increases thermogenesis and energy metabolism through modulation of the gut microbiota to confer resistance to cold temperatures

Published:4 September 2024 DOI: 10.1096/fj.202400870R PMID: 39230621
Chuanxin Sun, Juan Su, Jiarui Wang, Kan Ding, Chang Chen

Abstract

Traditional Chinese medical literature contains numerous records of many traditional Chinese herbal medicines that exhibit efficacy in enhancing resistance to cold, yet there is a lack of scientific explanation. Lycium barbarum is among the herbal medicines that are explicitly documented to enhance resistance to cold in the “Ben Cao Gang Mu (Compendium of Materia Medica)”. Herein, we investigated L. barbarum polysaccharide (LBP)-induced browning of inguinal white adipose tissue (iWAT), energy expenditure and thermogenic function in a long-term (4?months) treatment mouse model. LBP supplementation resulted in a significant reduction in weight and adipocyte size in iWAT, along with increased gut microbiota diversity. Specifically, the levels of Lachnospiraceae, Ruminococcaceae and Bacteroidaceae (short-chain fatty acid-producing bacteria) were elevated, leading to a higher level of short-chain fatty acids (SCFAs) in the caecal content. These effects subsequently triggered the release of glucagon-like peptide-1 (GLP-1) and activated the CREB/PGC1α signaling pathway in iWAT, thereby increasing energy expenditure and enhancing thermogenic function. The antibiotic treatment experiments confirmed that the LBP-mediated gut microbiota participated in the process of iWAT browning. In summary, our findings provide the first scientific explanation and mechanistic insights into the cold resistance of L. barbarum and identify potentially safe natural product supplements for individuals in alpine areas.

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Materials
Procduct Name CAS Molecular Formula Supplier Price
Neomycin sulfate 1405-10-3 C23H48N6O17S 906 suppliers $5.00-$1865.79
Neomycin sulfate 1405-10-3 C23H48N6O17S 906 suppliers $5.00-$1865.79
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