一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

ChemicalBook >> journal list >> Journal of pharmaceutical and biomedical analysis >>article
Journal of pharmaceutical and biomedical analysis

Journal of pharmaceutical and biomedical analysis

IF: 3.1
Download PDF

PK-PD relationship of poorly absorbable active ingredients from traditional Chinese medicines explaining by metabolic enzyme of gut microbiota: A case study of Dehydrocorydaline

Published:17 September 2024 DOI: 10.1016/j.jpba.2024.116478 PMID: 39306946
Xiaoting Gu , Yutian Cai , Chaoyue Zheng , Liuyao Xie , Linyi Zhang , Bingjie Lu , Shuwen Zhu , Yue Cui , Xiaoyu Ai , Cheng Yang

Abstract

Many active ingredients in traditional Chinese medicines generally have the characteristic of poor oral absorption but definite efficacy. It is necessary to establish a comprehensive technical system to explain the “PK-PD relationship” of them. Dehydrocorydaline (DHC), the quality control component in the Chinese patent drug “Kedaling Tablets”, has poor oral absorption but clear efficacy for coronary heart disease. Using DHC as a model drug, the changes in absorption and pharmacological effects of DHC in rats before and after inhibiting nitroreductase (NR) from gut microbiota were studied. The results showed that after inhibiting of NR activity, the plasma concentration of DHC in rats was decreased, the serum level of total cholesterol, triglyceride and low-density lipoprotein cholesterol were significantly increased. The levels of tumor necrosis factor-α, interleukin-1β, hypersensitive C-reactive protein, intercellular cell adhesion molecule-1 and Monocyte chemoattractant protein-1 were significantly increased, and pathological sections also showed that the efficacy of DHC decreased after inhibiting the activity of NR. We further investigated the drug metabolism of DHC under NR and found that DHC was metabolized into a hydrogenated metabolite, which may have stronger membrane permeability. In summary, NR may mediate the absorption degree and efficacy of DHC in vivo by metabolizing DHC into absorbable metabolite.

Substances (4)

Materials
Procduct Name CAS Molecular Formula Supplier Price
Diphenhydramine 58-73-1 C17H21NO 270 suppliers $10.00-$1673.60
Diphenhydramine 58-73-1 C17H21NO 270 suppliers $10.00-$1673.60
Diphenhydramine 58-73-1 C17H21NO 270 suppliers $10.00-$1673.60
Diphenhydramine 58-73-1 C17H21NO 270 suppliers $10.00-$1673.60

Similar articles

IF:8.5

Simulated digestion and gut microbiota fermentation of polysaccharides from Lactarius hatsudake Tanaka mushroom

Food Chemistry Qiao Yang, Songlin Chang,etc Published: 19 November 2024
IF:2.9

Therapeutic role of ursodeoxycholic acid in colitis-associated cancer via gut microbiota modulation.

ACS Chemical Health & Safety Qilang He,?Jinjie Wu,etc Published: 1 February 2023
IF:3.7

Efficient production of chemicals from microorganism by metabolic engineering and synthetic biology

Chinese Journal of Chemical Engineering Yang Zhang, Jing Yu,etc Published: 1 February 2021
社会| 敖汉旗| 鹤壁市| 奉新县| 通化市| 房山区| 罗定市| 合水县| 湖口县| 桦南县| 资阳市| 庆阳市| 阿巴嘎旗| 承德市| 珲春市| 屯昌县| 汉源县| 琼结县| 普定县| 桃江县| 沙洋县| 海口市| 嘉兴市| 泊头市| 福贡县| 南通市| 抚远县| 昌吉市| 邵东县| 晋中市| 五莲县| 沾化县| 昌图县| 察隅县| 长岭县| 墨玉县| 光山县| 新和县| 扎鲁特旗| 盐津县| 巴楚县|