一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

ChemicalBook >> journal list >> Journal of Functional Foods >>article
Journal of Functional Foods

Journal of Functional Foods

IF: 3.8
Download PDF

A natural protopanaxatriol from Panax notoginseng enhances osteosarcoma sensitivity to ferroptosis via ASCL4 upregulation

Published:30 September 2024 DOI: 10.1016/j.jff.2024.106488
Zhuo Chen, Renhua Ni, Yuanyu Hu, Yiyuan Yang, Yun Tian

Abstract

Current treatments for osteosarcoma, the most common primary bone cancer, including surgery, radiotherapy, and chemotherapy, are largely ineffective against metastatic and chemo-resistant cases, emphasizing the need for novel therapies. In this study, we investigated (20S)-Protopanaxatriol [(20S)-PPT], a natural product from Panax notoginseng, an herb used both as food and medicine, for its ability to enhance osteosarcoma sensitivity to ferroptosis induced by inducers such as RSL3, ML210, and IKE. Specifically, (20S)-PPT increased lipid peroxidation in osteosarcoma cells exposed to RSL3. This effect was mediated by ACSL4 upregulation, as ACSL4 knockdown reversed (20S)-PPT-sensitized ferroptosis. Importantly, (20S)-PPT significantly reduced tumor growth in xenograft models when combined with IKE. Collectively, our study confirms that combining (20S)-PPT with ferroptosis inducers offers a promising novel strategy for treating osteosarcoma.

Substances (64)

Materials
Procduct Name CAS Molecular Formula Supplier Price
Ginsenoside Rb1 41753-43-9 C54H92O23 498 suppliers $16.00-$2900.00
Ginsenoside Rb1 41753-43-9 C54H92O23 498 suppliers $16.00-$2900.00
Ginsenoside Rb1 41753-43-9 C54H92O23 498 suppliers $16.00-$2900.00
Ginsenoside Rb1 41753-43-9 C54H92O23 498 suppliers $16.00-$2900.00
Ginsenoside Rg1 22427-39-0 C42H72O14 464 suppliers $9.00-$3550.00
Ginsenoside Rg1 22427-39-0 C42H72O14 464 suppliers $9.00-$3550.00
Ginsenoside Rg1 22427-39-0 C42H72O14 464 suppliers $9.00-$3550.00
Ginsenoside Rg1 22427-39-0 C42H72O14 464 suppliers $9.00-$3550.00
Ginsenoside Re 52286-59-6 C48H82O18 387 suppliers $29.00-$1800.00
Ginsenoside Re 52286-59-6 C48H82O18 387 suppliers $29.00-$1800.00

Similar articles

IF:27.4

Additively Manufactured Biodegradable Zn‐Based Porous Scaffolds to Suppress Osteosarcoma and Promote Osteogenesis

Advanced Materials Yupu Lu, Aobo Liu,etc Published: 20 November 2024
IF:8.1

Complex IIa formation and ABC transporters determine sensitivity of OSCC to Smac mimetics

Cell Death & Disease Wang, Yuhan,etc Published: 22 November 2024
IF:0

Potential applications of ferulic acid from natural sources

Biotechnology Reports Naresh Kumar, Vikas Pruthi,etc Published: 1 December 2014
贺兰县| 武陟县| 玉林市| 江达县| 长宁县| 吉木萨尔县| 河北省| 河曲县| 麻栗坡县| 志丹县| 泗水县| 闽侯县| 文成县| 沙雅县| 韩城市| 米泉市| 扬中市| 开阳县| 齐齐哈尔市| 泸西县| 徐闻县| 常山县| 文山县| 莲花县| 宜宾市| 洛扎县| 香港 | 阿克| 商丘市| 雅江县| 鹤岗市| 青浦区| 尉氏县| 龙州县| 宣威市| 永靖县| 德兴市| 驻马店市| 洪雅县| 巫溪县| 巴林左旗|