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Journal of Functional Foods

Journal of Functional Foods

IF: 3.8
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A natural protopanaxatriol from Panax notoginseng enhances osteosarcoma sensitivity to ferroptosis via ASCL4 upregulation

Published:30 September 2024 DOI: 10.1016/j.jff.2024.106488
Zhuo Chen, Renhua Ni, Yuanyu Hu, Yiyuan Yang, Yun Tian

Abstract

Current treatments for osteosarcoma, the most common primary bone cancer, including surgery, radiotherapy, and chemotherapy, are largely ineffective against metastatic and chemo-resistant cases, emphasizing the need for novel therapies. In this study, we investigated (20S)-Protopanaxatriol [(20S)-PPT], a natural product from Panax notoginseng, an herb used both as food and medicine, for its ability to enhance osteosarcoma sensitivity to ferroptosis induced by inducers such as RSL3, ML210, and IKE. Specifically, (20S)-PPT increased lipid peroxidation in osteosarcoma cells exposed to RSL3. This effect was mediated by ACSL4 upregulation, as ACSL4 knockdown reversed (20S)-PPT-sensitized ferroptosis. Importantly, (20S)-PPT significantly reduced tumor growth in xenograft models when combined with IKE. Collectively, our study confirms that combining (20S)-PPT with ferroptosis inducers offers a promising novel strategy for treating osteosarcoma.

Substances (64)

Materials
Procduct Name CAS Molecular Formula Supplier Price
Ginsenoside Rb1 41753-43-9 C54H92O23 498 suppliers $16.00-$2900.00
Ginsenoside Rb1 41753-43-9 C54H92O23 498 suppliers $16.00-$2900.00
Ginsenoside Rb1 41753-43-9 C54H92O23 498 suppliers $16.00-$2900.00
Ginsenoside Rb1 41753-43-9 C54H92O23 498 suppliers $16.00-$2900.00
Ginsenoside Rg1 22427-39-0 C42H72O14 464 suppliers $9.00-$3550.00
Ginsenoside Rg1 22427-39-0 C42H72O14 464 suppliers $9.00-$3550.00
Ginsenoside Rg1 22427-39-0 C42H72O14 464 suppliers $9.00-$3550.00
Ginsenoside Rg1 22427-39-0 C42H72O14 464 suppliers $9.00-$3550.00
Ginsenoside Re 52286-59-6 C48H82O18 387 suppliers $29.00-$1800.00
Ginsenoside Re 52286-59-6 C48H82O18 387 suppliers $29.00-$1800.00

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