一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

ChemicalBook >> journal list >> Genomics >>article
Genomics

Genomics

IF: 3.4
Download PDF

Integrating transcriptomics and proteomics to understand the molecular mechanisms underlying the pathogenesis of type 2 diabetes mellitus

Published:1 November 2024 DOI: 10.1016/j.ygeno.2024.110964 PMID: 39571829
Shuyao Wei, Feifei Ma, Xiaoqin Ha

Abstract

The liver plays an important role in glucose regulation, and their dysfunction is closely associated with the development of type 2 diabetes mellitus (T2DM), and insulin resistance (IR) in hepatocyte mediate the pathogenesis of diabetes mellitus. In T2DM rats and their correlated control, we investigated various genes expression at transcriptional and translational level by utilizing transcriptomic using RNA sequencing (RNA-seq) and proteomics using isobaric tags for relative and absolute quantification (iTRAQ) to disclose potential candidates for Type 2 diabetes diagnosis and therapy. We found the lecithin retinol acyltransferase (Lrat) gene regulate hepatocyte IR in T2DM. Furthermore, BRL-3A cells, rat liver cells, worked as the IR model in vitro study. Hence, Lrat gene was overexpressed in BRL-3A cells to explore the role of Lrat gene in IR by measuring the cellular glucose consumption, TCHO, and LDL-C levels. Finally, we found that Lrat gene can improve the level of glycolipid metabolism in BRL-3A cells and reduce the degree of IR in BRL-3A cells. Therefore, further exploration of Lrat gene related molecular mechanism is meaningful.

Substances (7)

Materials
Procduct Name CAS Molecular Formula Supplier Price
D(+)-Glucose 50-99-7 C6H12O6 1451 suppliers $6.00-$26950.00
Bovine albumin 9048-46-8 N/A 914 suppliers $15.00-$18680.00
Deoxyribonuclease 9003-98-9 NULL 645 suppliers $52.00-$2400.00
INSULIN 11061-68-0 C257H383N65O77S6 349 suppliers $48.00-$3420.00
GLUCOSE 58367-01-4 C6H12O6 167 suppliers Inquiry
Streptomycin 57-92-1 C21H39N7O12 160 suppliers Inquiry
INSULIN 9004-10-8 C256H381N65O77S6 48 suppliers Inquiry

Similar articles

IF:13

Linagliptin: in type 2 diabetes mellitus.

Drugs Lesley J Scott,etc Published: 26 March 2011
IF:13

Dapagliflozin: a review of its use in type 2 diabetes mellitus.

Drugs Greg L Plosker,etc Published: 3 December 2012
IF:0

Teneligliptin: DPP-4 inhibitor in the treatment of type II Diabetes Mellitus

International Journal of Phytopharmacy K. Danao, M. Shende,etc Published: 30 August 2017
西贡区| 邹平县| 定结县| 南昌县| 开阳县| 佛冈县| 新和县| 绥化市| 彰化县| 娄烦县| 土默特左旗| 嘉禾县| 荣成市| 嘉祥县| 平乐县| 靖西县| 调兵山市| 苗栗市| 西华县| 宁晋县| 琼海市| 湖口县| 张北县| 赤峰市| 探索| 石嘴山市| 漾濞| 通渭县| 盐亭县| 峡江县| 马关县| 鄄城县| 宁强县| 富民县| 翼城县| 宁波市| 固始县| 贵港市| 体育| 汽车| 邯郸县|