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Genomics

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Integrating transcriptomics and proteomics to understand the molecular mechanisms underlying the pathogenesis of type 2 diabetes mellitus

Published:1 November 2024 DOI: 10.1016/j.ygeno.2024.110964 PMID: 39571829
Shuyao Wei, Feifei Ma, Xiaoqin Ha

Abstract

The liver plays an important role in glucose regulation, and their dysfunction is closely associated with the development of type 2 diabetes mellitus (T2DM), and insulin resistance (IR) in hepatocyte mediate the pathogenesis of diabetes mellitus. In T2DM rats and their correlated control, we investigated various genes expression at transcriptional and translational level by utilizing transcriptomic using RNA sequencing (RNA-seq) and proteomics using isobaric tags for relative and absolute quantification (iTRAQ) to disclose potential candidates for Type 2 diabetes diagnosis and therapy. We found the lecithin retinol acyltransferase (Lrat) gene regulate hepatocyte IR in T2DM. Furthermore, BRL-3A cells, rat liver cells, worked as the IR model in vitro study. Hence, Lrat gene was overexpressed in BRL-3A cells to explore the role of Lrat gene in IR by measuring the cellular glucose consumption, TCHO, and LDL-C levels. Finally, we found that Lrat gene can improve the level of glycolipid metabolism in BRL-3A cells and reduce the degree of IR in BRL-3A cells. Therefore, further exploration of Lrat gene related molecular mechanism is meaningful.

Substances (7)

Materials
Procduct Name CAS Molecular Formula Supplier Price
D(+)-Glucose 50-99-7 C6H12O6 1451 suppliers $6.00-$26950.00
Bovine albumin 9048-46-8 N/A 914 suppliers $15.00-$18680.00
Deoxyribonuclease 9003-98-9 NULL 645 suppliers $52.00-$2400.00
INSULIN 11061-68-0 C257H383N65O77S6 349 suppliers $48.00-$3420.00
GLUCOSE 58367-01-4 C6H12O6 167 suppliers Inquiry
Streptomycin 57-92-1 C21H39N7O12 160 suppliers Inquiry
INSULIN 9004-10-8 C256H381N65O77S6 48 suppliers Inquiry

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