一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

ChemicalBook >> journal list >> JOURNAL OF CELLULAR AND MOLECULAR MEDICINE >>article
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

IF: 5.3
Download PDF

HBSP inhibits tubular cell pyroptosis and apoptosis, promotes macrophage M2 polarization, and protects LPS‐induced acute kidney injury

Published:25 November 2024 DOI: 10.1111/jcmm.70202
Lili Huang, Yuanyuan Wu, Wenli Sai, Yanan Wang, Guijuan Feng, Yuqing Lu, Fei Chen, Xinzhong Huang, Hongsheng Zhao, Zhifeng Gu, Bin Yang

Abstract

Sepsis-associated acute kidney injury (AKI) has high morbidity and mortality, but without cause-specific treatment. Erythropoietin derived Helix B surface peptide (HBSP) alleviates AKI, whereas its underlying mechanisms remain to be further explored. Here, the effects of HBSP on pyroptosis, apoptosis, macrophage polarization and repair were investigated in lipopolysaccharide (LPS)-induced AKI mouse model and cultured kidney epithelial cells. Systemic inflammation, compromised renal function and histology were demonstrated in LPS-treated mice, with upregulated pyroptotic and apoptotic key proteins in the kidneys including GSDMD-N, cleaved IL-1β, IL-18 and caspase-3. These proteins were localized in tubular areas and colocalized with aquaporin-1 (AQP1), with increased F4/80+ M1 macrophages. However, HBSP mitigated pyroptosis, apoptosis and inflammation, and promoted macrophage M2 polarization. In addition, HMGB1 and erythropoietin receptor (EPOR) were increased by LPS and decreased by HBSP, both of which were positively correlated with pyroptotic and apoptotic proteins. Moreover, HBSP reduced TNF-α and IL-6 mRNA levels, as well as pyroptosis and apoptosis in LPS-stimulated TCMK-1 cells. In conclusion, HBSP inhibited tubular pyroptosis and apoptosis, EPOR expression, promoted macrophage M2 polarization, and protected against LPS-induced AKI. These findings provide new mechanistic insights into the renoprotection of HBSP, and facilitate its potential for clinical applications and therapeutic strategies in sepsis-associated AKI.

Substances (1)

Materials
Procduct Name CAS Molecular Formula Supplier Price
Isoflurane 26675-46-7 C3H2ClF5O 267 suppliers $19.00-$2616.08

Similar articles

IF:4.3

Dihydromyricetin inhibits cell proliferation, migration, invasion and promotes apoptosis via regulating miR-21 in Human Cholangiocarcinoma Cells.

ACS Applied Electronic Materials Lei Chen, Zhou-Sheng Yang,etc Published: 29 July 2020
IF:0.7

Alfacalcidol-Induced Kidney Injury in Patients with Severe Motor and Intellectual Disabilities.

Journal of nutritional science and vitaminology Osamu Uemura,?Yuka Hasegawa,etc Published: 1 January 2024
IF:0

Evaluation of the Effect of Aminophylline in Reducing the Incidence of Acute Kidney Injury After Cardiac Surgery.

Anesthesiology and Pain Medicine Shahrbanoo Shahbazi, Peyman Alishahi,etc Published: 27 August 2017
资中县| 渝中区| 宁武县| 信宜市| 宜兰市| 马关县| 凌源市| 张掖市| 治县。| 通榆县| 吕梁市| 瑞金市| 合作市| 濮阳市| 南开区| 平和县| 库尔勒市| 镇安县| 中方县| 喀喇| 阿鲁科尔沁旗| 杭州市| 潮安县| 祥云县| 凌海市| 汤原县| 克东县| 山东| 依安县| 苍梧县| 青阳县| 桦甸市| 娄烦县| 宜宾市| 永新县| 花莲县| 南木林县| 布拖县| 遂川县| 青海省| 茂名市|