一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

ChemicalBook >> journal list >> Advanced Science >>article
Advanced Science

Advanced Science

IF: 14.3
Download PDF

Tubular MYDGF Slows Progression of Chronic Kidney Disease by Maintaining Mitochondrial Homeostasis

Published:26 November 2024 DOI: 10.1002/advs.202409756 PMID: 39587987
Xiaohan Liu, Yang Zhang, Youzhao Wang, Yujie Yang, Zhe Qiao, Ping Zhan, Huiying Jin, Qianqian Xu, Wei Tang, Yu Sun, Yan Zhang, Fan Yi, Min Liu

Abstract

Mitochondrial dysfunction is a key event driving the maladaptive repair of tubular epithelial cells during the transition from acute kidney injury to chronic kidney disease (CKD). Therefore, identifying potential targets involved in mitochondrial dysfunction in tubular epithelial cells is clinically important. Myeloid-derived growth factor (MYDGF), a novel secreted protein, plays important roles in multiple cardiovascular diseases, but the function of MYDGF in tubular epithelial cells remains unknown. In the present study, it is found that MYDGF expression is significantly reduced in the cortex of the kidney, especially in the proximal tubules, from mice with CKD. Notably, lower expression of MYDGF is observed in tubules from patients with CKD and the level of MYDGF correlated with key factors related to kidney fibrosis and estimated glomerular filtration rate (eGFR) in patients with CKD. Tubule-specific deletion of Mydgf exacerbates kidney injury in mice with CKD; however, Mydgf overexpression attenuates kidney fibrosis by remodeling mitochondrial homeostasis in tubular epithelial cells. Mechanistically, renal tubular MYDGF positively regulates the expression of isocitrate dehydrogenase 2 (IDH2), restores mitochondrial homeostasis, and slows CKD progression. Thus, this study indicates that MYDGF derived from tubules may be an effective therapeutic strategy for patients with CKD.

Substances (2)

Materials
Procduct Name CAS Molecular Formula Supplier Price
Folic acid 59-30-3 C19H19N7O6 1511 suppliers $5.00-$1269.63
Aristolochic acid 313-67-7 C17H11NO7 338 suppliers $14.00-$1849.00

Similar articles

IF:4.4

ACVR1 mediates renal tubular EMT in kidney fibrosis via AKT activation

Cellular signalling Tianli Yu, Zhangyu Mai,etc Published: 23 November 2024
IF:5.3

HBSP inhibits tubular cell pyroptosis and apoptosis, promotes macrophage M2 polarization, and protects LPS‐induced acute kidney injury

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE Lili Huang, Yuanyuan Wu,etc Published: 25 November 2024
鄂托克前旗| 澄迈县| 什邡市| 遂平县| 沙坪坝区| 商城县| 五指山市| 辽中县| 南开区| 温州市| 陵川县| 建德市| 菏泽市| 遂宁市| 山丹县| 当雄县| 曲麻莱县| 睢宁县| 琼海市| 秦安县| 鹿泉市| 嘉义县| 北宁市| 琼中| 如皋市| 麦盖提县| 广灵县| 山西省| 麻阳| 石台县| 凌源市| 丽江市| 平湖市| 拜城县| 内乡县| 涞水县| 罗田县| 鸡西市| 东阿县| 沙湾县| 兰考县|