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Chemistry - An Asian Journal

Chemistry - An Asian Journal

IF: 3.5
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Quinoline Endoperoxides for Mitochondria Targeted Singlet Oxygen Delivery

Published:29 November 2024 DOI: 10.1002/asia.202401051 PMID: 39611807
Yu Si, Lei Wang, Hao Wu, Shoucai Yan, Yang Wang, Xiao Qian, Ziang Liu, Engin U. Akkaya

Abstract

Controlled release of singlet oxygen from chemical sources is becoming an interesting path for eliciting apoptotic death of cancer cells. In this work, we present the synthesis and characterization of hitherto unknown class of aromatic endoperoxides, namely quinoline endoperoxides. Quinolines, especially after quaternization, show significant targeting of mitochondria. This leads to more effective cytotoxicity in cancer cell cultures suggesting a potential utility in cancer therapy.

Substances (1)

Materials
Procduct Name CAS Molecular Formula Supplier Price
4',6-Diamidino-2-phenylindole dihydrochloride 28718-90-3 C16H16ClN5 610 suppliers $15.00-$4800.00

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