一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

ChemicalBook >> journal list >> International Journal of Pharmaceutics >>article
International Journal of Pharmaceutics

International Journal of Pharmaceutics

IF: 5.3
Download PDF

Elastic liposomes for skin delivery of dipotassium glycyrrhizinate

Published:25 July 2002 DOI: 10.1016/S0378-5173(02)00266-1
M Trotta, E Peira, F Debernardi, M Gallarate

Abstract

The aim of this study was to evaluate the possibility of using liposomes for skin delivery of dipotassium glycyrrhizinate (KG), an anti-inflammatory agent employed in treating acute and chronic dermatitis, and of formulating such liposomes in an oil-in-water emulsion (O/W). KG had emulsifying properties and the possibility of producing elastic liposomes was verified. Liposomes containing soya lecithin (PC) or hydrogenated soya lecithin (HPC) mixed with KG in w/w ratios of 2:1, 4:1 or 8:1 were prepared by the solvent evaporation method and then passed through a high pressure homogeniser. Liposome size and entrapment efficiency were determined and the interaction between KG and HPC was investigated using differential scanning calorimetry (DSC). Transepidermal permeation through intact pig skin and skin deposition of KG from liposomes and O/W emulsion containing liposomes were assessed and compared with values for aqueous control solutions. No marked differences were observed between PC and HPC liposomes. Liposome sizes ranged from 90 to 120 nm. Entrapment efficiency depended on the lipid:KG ratio; the maximum efficiency was obtained at 4:1 w/w. KG interacted with liposomes disrupting and fluidising the lipid bilayer, forming elastic liposomes able to penetrate through membrane pores of diameter much smaller than their own diameter. The liposome structure was maintained when dispersed in an O/W emulsion. The skin fluxes were less than the HPLC detection limit for all systems, while skin deposition increased 4.5-fold compared with aqueous solutions when KG was formulated in liposomes.

Substances (3)

Related products
Procduct Name CAS Molecular Formula Supplier Price
Dipotassium glycyrrhizinate 68797-35-3 C42H63KO16 600 suppliers $14.00-$1236.00
Soya lecithin 308068-11-3 57 suppliers Inquiry
Formic acid HPLC CH2O2 3 suppliers Inquiry

Similar articles

IF:1.1

Effects of dipotassium glycyrrhizinate on wound healing.

Acta cirurgica brasileira Camila Dos Santos Leite, Oscar César Pires,etc Published: 8 October 2021
IF:5.4

Usage of Synthetic Peptides in Cosmetics for Sensitive Skin.

ACS Applied Energy Materials Diana I S P Resende, Marta Salvador Ferreira,etc Published: 21 July 2021
IF:3.5

Quinoline Endoperoxides for Mitochondria Targeted Singlet Oxygen Delivery

Chemistry - An Asian Journal Yu Si, Lei Wang,etc Published: 29 November 2024
泗阳县| 日照市| 九台市| 泾阳县| 庆安县| 罗城| 齐齐哈尔市| 利川市| 夏河县| 苍山县| 武强县| 个旧市| 金溪县| 贡嘎县| 安福县| 弥勒县| 白山市| 米易县| 青海省| 保山市| 讷河市| 淳安县| 石台县| 仙游县| 韶关市| 高州市| 贵德县| 荔波县| 礼泉县| 若尔盖县| 基隆市| 丰县| 化德县| 湟源县| 乐业县| 龙海市| 广平县| 平昌县| 泰和县| 白水县| 娄底市|