一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

ChemicalBook >> journal list >> Neurogastroenterology and Motility >>article
Neurogastroenterology and Motility

Neurogastroenterology and Motility

IF: 3.5
Download PDF

Electroacupuncture at Zusanli (ST36) Alleviate Intestinal Ischemia-Reperfusion Injury by Regulating the Cholinergic-miRNA 124 Pathway

Published:1 December 2024 DOI: 10.1111/nmo.14971 PMID: 39618028
YanXia Geng,?Hai Lv,?Yu Liu,?DingDing Guo,?JingJing Zheng,?YingXin Li,?Hua Jiang,?Dong Chen

Abstract

Objective: Intestinal ischemia-reperfusion injury (IIRI) is common in a variety of critical diseases and acute stress, and acupuncture is a promising treatment for IIRI. The aim of this study is to explore the mechanism of electroacupuncture (EA) at Zusanli (ST36) in improving IIRI from the perspective of the cholinergic anti-inflammatory pathway (CAP) and miRNA 124.

Methods: Seven groups of mice were performed: Control group, I/R group (IIRI model), EA group (I/R?+?EA), miRNA mimic group (I/R?+?EA?+?miRNA 124 mimic), miRNA inhibitor group (I/R?+?EA?+?miRNA 124 inhibitor), PNU group (I/R?+?EA?+?α7nAChR agonist), and MLA group (I/R?+?EA+ α7nAChR antagonist). The expression of intestinal macrophages, α7nAChR, miRNA 124, and related molecules, including p-STAT3 and IL-6, as well as histological damage (Chiu's score) and mucosal permeability (serum FD4 concentration), were detected.

Results: The serum FD4 concentrations in the EA and PNU groups were significantly lower compared to the I/R group (p?

Conclusion: EA at Zusanli may induce miRNA124 through the cholinergic pathway on intestinal macrophages, which may be a key neuro-immune target of EA in the treatment of IIRI.

Substances (4)

Materials
Procduct Name CAS Molecular Formula Supplier Price
N-(3R)-1-AZABICYCLO[2.2.2]OCT-3-YL-4-CHLOROBENZAMIDE 123464-89-1 C14H17ClN2O 160 suppliers $9.00-$5653.73
N-(3R)-1-AZABICYCLO[2.2.2]OCT-3-YL-4-CHLOROBENZAMIDE 123464-89-1 C14H17ClN2O 160 suppliers $9.00-$5653.73
N-(3R)-1-AZABICYCLO[2.2.2]OCT-3-YL-4-CHLOROBENZAMIDE 123464-89-1 C14H17ClN2O 160 suppliers $9.00-$5653.73
N-(3R)-1-AZABICYCLO[2.2.2]OCT-3-YL-4-CHLOROBENZAMIDE 123464-89-1 C14H17ClN2O 160 suppliers $9.00-$5653.73

Similar articles

IF:3

Neuroprotective effects of phenylacetylglycine via β2AR on cerebral ischemia/reperfusion injury in rats

Saudi Pharmaceutical Journal Wenjie Hu, Xueyan Kuang,etc Published: 1 December 2024
IF:3.7

Acesulfame potassium induces dysbiosis and intestinal injury with enhanced lymphocyte migration to intestinal mucosa

Journal of Gastroenterology and Hepatology Yoshinori Hanawa, Masaaki Higashiyama,etc Published: 8 August 2021
IF:5.3

BMP10 Knockdown Modulates Endothelial Cell Immunoreactivity by Inhibiting the HIF‐1α Pathway in the Sepsis‐Induced Myocardial Injury

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE Huan Guan, Jingyun Fang,etc Published: 29 November 2024
天门市| 凤翔县| 武威市| 盐池县| 铜鼓县| 从江县| 韩城市| 彝良县| 台湾省| 新巴尔虎右旗| 澄迈县| 当雄县| 海口市| 崇仁县| 宜阳县| 吉林市| 西盟| 沂源县| 长阳| 平武县| 且末县| 石渠县| 崇明县| 五华县| 江华| 平舆县| 弥渡县| 辽阳市| 兴化市| 尉氏县| 柏乡县| 南康市| 横峰县| 金寨县| 冷水江市| 乌鲁木齐市| 肥城市| 西峡县| 廉江市| 霍山县| 肥东县|