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Chemical Engineering Journal

Chemical Engineering Journal

IF: 13.3
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ZnCur nanoparticle-enhanced multifunctional hydrogel platform: Synergistic antibacterial and immunoregulatory effects for infected diabetic wound healing

Published:7 December 2024 DOI: 10.1016/j.cej.2024.158387
Yan-Wen Ding, Zhi-Wei Zhang, Xin-Yu Cui, Rui-Yang Hu, Yang Li, Si-Da Huang, Si-Qi Du, Jin-Wei Dao, Dai-Xu Wei

Abstract

Treating diabetic wounds poses significant challenges due to the complex wound microenvironment, including bacterial infection, oxidative stress, inflammation, and impaired angiogenesis. We developed a novel curcumin nanoparticle formulation (ZnCur NPs) with excellent water dispersibility and stability, showcasing strong antibacterial, antioxidant, and anti-inflammatory properties. By encapsulating these ZnCur NPs along with RL-QN15 short peptides (with the function of promoting tissue repair and angiogenesis) into a hydrogel (CSA-OHAMA hydrogel, CO) based on chitosan and hyaluronic acid, we created a multifunctional hydrogel platform (Z/P/CO) that integrates antibacterial and immune-modulating functions. The Z/P/CO hydrogels are self-healing and adhesive, adapting to wound shapes while providing a protective barrier that minimizes bacterial invasion and maintains a moist environment. They effectively deliver ZnCur NPs and RL-QN15 peptides, enhancing antibacterial action and reshaping the adverse wound microenvironment. In vitro and in vivo results demonstrated that Z/P/CO significantly reduced inflammation, promoted angiogenesis, and facilitated collagen deposition, accelerating the healing of infected diabetic wounds within 17?days. This integrated hydrogel platform offers a promising strategy and effective method for treating diabetic wounds by reshaping the immune microenvironment.

Substances (3)

Materials
Procduct Name CAS Molecular Formula Supplier Price
Sodium hydroxide 1310-73-2 NaOH 1357 suppliers $14.00-$17490.00
Chitosan 9012-76-4 C6H11NO4X2 1019 suppliers $13.00-$4250.00
Hyaluronic acid 9004-61-9 C14H22NNaO11 700 suppliers $36.00-$3115.20

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