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ACS Applied Materials & Interfaces

ACS Applied Materials & Interfaces

IF: 8.3
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Ultrasound-Triggered Nanogel Boosts Chemotherapy and Immunomodulation in Colorectal Cancer

Published:11 December 2024 DOI: 10.1021/acsami.4c13358
Rui Cui, Jingwen Zhou, Wei Yang, Yao Chen, Limei Chen, Lei Tan, Feng Zhang, Guangjian Liu, Jie Yu

Abstract

Chemotherapy is the primary therapy for colorectal cancer. However, its efficacy has been limited by chemoresistance, which is mainly caused by inadequate intratumoral drug accumulation and immunosuppressive microenvironments. To address these limitations, we developed a low-intensity ultrasound (LIU)-controlled and charge-reversible nanogel (R-NG), utilizing conjugated chitosan-polypyrrole polymers linked via thioketal bonds, with TiO2 absorbed onto its surface. Following the loading of oxaliplatin, the Oxa-R-NGs were ultimately synthesized. In the acidic tumor environment, the protonation of the pyrrole ring triggered the conversion of Oxa-R-NG into a positively charged form, thereby enhancing tumor penetration and cellular internalization. Based on the charge conversion, intratumoral accumulating Oxa-R-NG was triggered by LIU to continuously generate reactive oxygen species (ROS), which not only disrupted thioketal bonds to liberate oxaliplatin but also regulated tumor-associated macrophage polarization. Consequently, Oxa-R-NG boosted the chemotherapy for colorectal cancer by improving intratumoral drug accumulation and reversing the local immunosuppressive microenvironment synergistically.

Substances (10)

Materials
Procduct Name CAS Molecular Formula Supplier Price
Acetic acid 64-19-7 C2H4O2 1775 suppliers $10.00-$9280.00
Sodium hydroxide 1310-73-2 NaOH 1358 suppliers $14.00-$17490.00
N-Hydroxysuccinimide 6066-82-6 C4H5NO3 1030 suppliers $4.00-$3650.00
Pyridine 110-86-1 C5H5N 976 suppliers $9.00-$25600.00
Ethanol 64-17-5 C2H6O 955 suppliers $10.00-$28350.00
Cyclohexane 110-82-7 C6H12 841 suppliers $10.00-$8580.00
Ammonium persulfate 7727-54-0 H8N2O8S2 768 suppliers $10.16-$3100.00
Titanium dioxide 13463-67-7 O2Ti 768 suppliers $9.00-$12090.00
Span 80 1338-43-8 C24H44O6 647 suppliers $5.00-$497.42
D-Luciferin potassium salt 115144-35-9 C11H9KN2O3S2 551 suppliers $10.00-$4173.50

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