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Science Advances

Science Advances

IF: 11.7
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Framework nucleic acid strategy enables closer microbial contact for programming short-range interaction

Published:13 December 2024 DOI: 10.1126/sciadv.adr4399 PMID: 39661693
Na Chen,?Jing Xi,?Na Du,?Ruichen Shen,?Rui Zhao,?Wei He,?Tianhuang Peng,?Yanbing Yang,?Yun Zhang,?Lilei Yu,?Weihong Tan,?Quan Yuan

Abstract

Programming precise and specific microbial intraspecies or interspecies interaction would be powerful for microbial metabolic regulation, signal pathway mechanism understanding, and therapeutic application. However, it is still of great challenge to develop a simple and universal method to artificially encode the microbial interactions without interfering with the intrinsic cell metabolism. Here, we proposed an extensible and flexible framework nucleic acid strategy for encoding the specific and precise microbial interactions upon self-assembly. With this spatial manipulation tool, we propose the microbial spatial heterogeneity and short-range interaction mechanism that the microbial assembly facilitates the gene expressions of the surface sensors including flagella and pili in Pseudomonas aeruginosa, leading to a more sensitive response to quorum sensing. The microbial interaction programming strategy proposed in this work is expected to provide a powerful and designable nanoplatform for better understanding of distance-dependent bacterial communication networks.

Substances (9)

Materials
Procduct Name CAS Molecular Formula Supplier Price
Sodium chloride 7647-14-5 ClNa 1690 suppliers $5.00-$6678.62
Acetonitrile 75-05-8 C2H3N 1117 suppliers $10.00-$245834.00
Methanol 67-56-1 CH4O 896 suppliers $9.00-$19915.10
Agar 9002-18-0 C14H24O9 812 suppliers $14.00-$4510.00
Agarose 9012-36-6 C10H15N3O3 731 suppliers $18.53-$3090.00
Penicillin G sodium salt 69-57-8 C16H17N2NaO4S 523 suppliers $12.00-$1449.25
Peptone 73049-73-7 C13H24O4 505 suppliers $27.00-$6924.80
Streptomycin 57-92-1 C21H39N7O12 160 suppliers Inquiry
FETUIN 9014-81-7 NULL 92 suppliers $37.07-$4810.00
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