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Toxicology letters

Toxicology letters

IF: 2.9
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The covalent interaction of 1,4-dibromobenzene with rat and mouse nucleic acids: in vivo and in vitro studies

Published:1 December 1990 DOI: 10.1016/0378-4274(90)90174-K PMID: 1701931
Annamaria Colacci , Silvana Bartoli , Bruna Bonora , Mario Mazzullo , Alessandra Niero , Paolo Perocco , Paola Silingardi , Sandro Grilli

Abstract

1,4-Dibromobenzene (1,4-DBB) was covalently bound to DNA from liver, kidney, lung and stomach of mice after intraperitoneal administration. The covalent binding index (CBI) value (23 in mouse liver) was typical of weak initiators. On the contrary, no interaction with DNA from rat organs was observed (CBI detection limit: 1.3–2.6). The in vitro interaction of 1,4-DBB with calf thymus DNA was mediated mainly by microsomes, especially those from liver of both species and from mouse lung. Mouse subcellular fractions were more active then rat subcellular fractions. Unlike liver cytosol, subcellular cytosolic fractions from lung, kidney and stomach were capable of bioactivating 1,4-DBB, although to a lesser extent than liver microsomes. Both cytochrome P-450 and GSH-transferases are involved in 1,4-DBB bioactivation.

Substances (4)

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Procduct Name CAS Molecular Formula Supplier Price
1,4-Dibromobenzene 106-37-6 C6H4Br2 581 suppliers $7.62-$1570.25
DEOXYRIBONUCLEIC ACID 100403-24-5 Null 266 suppliers $61.40-$459.56
DNA sodium salt 73049-39-5 NULL 169 suppliers $25.00-$3450.00
cytochrome P-450 2A7 10 suppliers Inquiry

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