一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

ChemicalBook >> journal list >> Journal of Agricultural and Food Chemistry >>article
Journal of Agricultural and Food Chemistry

Journal of Agricultural and Food Chemistry

IF: 5.7
Download PDF

4-Methylumbelliferone Inhibits Angiogenesis in Vitro and in Vivo

Published:12 April 2013 DOI: 10.1021/jf303062h PMID: 23581646
Javier A. García-Vilas, Ana R. Quesada, Miguel ángel Medina*

Abstract

4-Methylumbelliferone (4-MU) is a hyaluronic acid biosynthesis inhibitor with antitumoral and antimetastatic effects. The objective of the present study was to determine the potential of 4-MU as an antiangiogenic compound. To fulfill this aim, cultured endothelial cells were used to perform an array of in vitro assays, as well as two different in vivo angiogenesis assays. This study demonstrates that, in fact, 4-MU behaves as a new inhibitor of both in vitro and in vivo angiogenesis. In vitro, 4-MU affects several key steps of angiogenesis, including endothelial cell proliferation, adhesion, tube formation, and extracellular matrix remodeling. Half-maximal inhibitory concentrations (IC50) values in the proliferation assay were 0.65 ± 0.04 and 0.37 ± 0.03 mM for HMEC and RF-24 endothelial cells, respectively. 4-MU (2 mM) treatment for 24 h induced apoptosis in 13% of HMEC and 5% of RF-24 cells. The number of adherent endothelial cells decreased by >20% after 24 h of treatment with 1 mM 4-MU. Minimal inhibitory concentrations in the tube formation assay were 2 and 0.5 mM 4-MU for HMEC and RF-24, respectively. Matrix metalloproteinase-2 expression was differentially altered upon 4-MU treatment in both tested endothelial cell lines. Taken together, the results suggest that 4-MU may have potential as a new candidate multitargeted bioactive compound for antiangiogenic therapy.

Substances (2)

Related products
Procduct Name CAS Molecular Formula Supplier Price
4-Methylumbelliferone 90-33-5 C10H8O3 740 suppliers $7.00-$898.00
Hyaluronic acid 9004-61-9 C14H22NNaO11 701 suppliers $36.00-$1066.65

Similar articles

IF:3.8

Salidroside inhibits the growth of human breast cancer in vitro and in vivo.

Oncology reports Gang Zhao, Aiping Shi,etc Published: 1 May 2015
IF:4.6

In Vitro and In Vivo Neuroprotective Effects of Sarcosine.

ACS Applied Bio Materials Arzugül Tanas, ?zlem ?zdemir Tozlu,etc Published: 15 October 2022
IF:8.3

4-methylumbelliferone treatment and hyaluronan inhibition as a therapeutic strategy in inflammation, autoimmunity, and cancer.

ACS Applied Materials & Interfaces Nadine Nagy, Hedwich F Kuipers,etc Published: 23 March 2015
江阴市| 天台县| 张北县| 乳山市| 通江县| 澎湖县| 北碚区| 芜湖市| 保定市| 丹寨县| 茌平县| 华阴市| 分宜县| 萨嘎县| 长宁区| 田东县| 保亭| 灌阳县| 阳泉市| 方城县| 水富县| 平陆县| 望奎县| 安义县| 莱阳市| 东至县| 洞头县| 瓦房店市| 五峰| 家居| 延边| 习水县| 浦北县| 福建省| 平泉县| 西乌珠穆沁旗| 阳新县| 于都县| 准格尔旗| 河东区| 阿合奇县|