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ACS Applied Materials & Interfaces

ACS Applied Materials & Interfaces

IF: 8.3
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4-methylumbelliferone treatment and hyaluronan inhibition as a therapeutic strategy in inflammation, autoimmunity, and cancer.

Published:23 March 2015 DOI: 10.3389/fimmu.2015.00123 PMID: 25852691
Nadine Nagy, Hedwich F Kuipers, Adam R Frymoyer, Heather D Ishak, Jennifer B Bollyky, Thomas N Wight, Paul L Bollyky

Abstract

Hyaluronan (HA) is a prominent component of the extracellular matrix at many sites of chronic inflammation, including type 1 diabetes (T1D), multiple sclerosis, and numerous malignancies. Recent publications have demonstrated that when HA synthesis is inhibited using 4-methylumbelliferone (4-MU), beneficial effects are observed in several animal models of these diseases. Notably, 4-MU is an already approved drug in Europe and Asia called "hymecromone" where it is used to treat biliary spasm. However, there is uncertainty regarding how 4-MU treatment provides benefit in these animal models and the potential long-term consequences of HA inhibition. Here, we review what is known about how HA contributes to immune dysregulation and tumor progression. Then, we review what is known about 4-MU and hymecromone in terms of mechanism of action, pharmacokinetics, and safety. Finally, we review recent studies detailing the use of 4-MU to treat animal models of cancer and autoimmunity.

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Related products
Procduct Name CAS Molecular Formula Supplier Price
4-Methylumbelliferone 90-33-5 C10H8O3 740 suppliers $7.00-$898.00
Hyaluronan (Ultra Low MW) 4 suppliers Inquiry

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