一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

ChemicalBook >> journal list >> Advanced Science >>article
Advanced Science

Advanced Science

IF: 14.3
Download PDF

Liver-Secreted Extracellular Vesicles Promote Cirrhosis-Associated Skeletal Muscle Injury Through mtDNA-cGAS/STING Axis

Published:13 January 2025 DOI: 10.1002/advs.202410439 PMID: 39804962
Xiaoli Fan, Yunke Peng, Bo Li, Xiaoze Wang, Yifeng Liu, Yi Shen, Guofeng Liu, Yanyi Zheng, Qiaoyu Deng, Jingping Liu, Li Yang

Abstract

Skeletal muscle atrophy (sarcopenia) is a serious complication of liver cirrhosis, and chronic muscle inflammation plays a pivotal role in its pathologenesis. However, the detailed mechanism through which injured liver tissues mediate skeletal muscle inflammatory injury remains elusive. Here, it is reported that injured hepatocytes might secrete mtDNA-enriched extracellular vesicles (EVs) to trigger skeletal muscle inflammation by activating the cGAS-STING pathway. Briefly, injured liver secreted increased amounts of EVs into circulation, which are then engulfed primarily by macrophages in skeletal muscle and subsequently induce cGAS-STING signaling and its-mediated inflammatory response in muscles. In contrast, suppression of hepatic EV secretion or STING signaling significantly alleviated cirrhosis-induced skeletal muscle inflammation and muscle atrophy in vivo. Circulating EVs from cirrhotic patients showed higher levels of mtDNA, and the levels of EV-mtDNA positively correlated with the severity of liver injury. In injured hepatocytes, mitochondrial damage promoted the release of cytosolic mtDNA and the subsequent secretion of mtDNA-enriched EVs. This study reveals that injured hepatocyte-derived EVs induce skeletal muscle inflammation via the mtDNA?STING axis, while targeted blockade of liver EV secretion or STING signaling represents a potential therapeutic approach for preventing cirrhosis-associated skeletal muscle atrophy.

Substances (12)

Materials
Procduct Name CAS Molecular Formula Supplier Price
BAY 11-7085 196309-76-9 C13H15NO2S 135 suppliers $15.00-$5744.00
BAY 11-7085 196309-76-9 C13H15NO2S 135 suppliers $15.00-$5744.00
BAY 11-7085 196309-76-9 C13H15NO2S 135 suppliers $15.00-$5744.00
BAY 11-7085 196309-76-9 C13H15NO2S 135 suppliers $15.00-$5744.00
1-(4-ethylphenyl)-3-(1H-indol-3-yl)urea 941987-60-6 C17H17N3O 113 suppliers $9.79-$1872.00
1-(4-ethylphenyl)-3-(1H-indol-3-yl)urea 941987-60-6 C17H17N3O 113 suppliers $9.79-$1872.00
1-(4-ethylphenyl)-3-(1H-indol-3-yl)urea 941987-60-6 C17H17N3O 113 suppliers $9.79-$1872.00
1-(4-ethylphenyl)-3-(1H-indol-3-yl)urea 941987-60-6 C17H17N3O 113 suppliers $9.79-$1872.00
Cenicriviroc 497223-25-3 C41H52N4O4S 107 suppliers $60.00-$20790.00
Cenicriviroc 497223-25-3 C41H52N4O4S 107 suppliers $60.00-$20790.00

Similar articles

IF:15.5

Glycoengineered extracellular vesicles released from antibacterial hydrogel facilitate diabetic wound healing by promoting angiogenesis

Journal of Extracellular Vesicles Kewei Wang, Qin He,etc Published: 27 November 2024
IF:2.4

Creatine monohydrate use is prospectively associated with muscle dysmorphia symptomatology

Eating behaviors Kyle T. Ganson , Alexander Testa ,etc Published: 1 August 2024
IF:5.3

Synthesis, physicochemical and biological evaluation of 2-amino-5-chlorobenzophenone derivatives as potent skeletal muscle relaxants

Arabian Journal of Chemistry Rajesh K. Singh, Sonia Devi ,etc Published: 1 May 2015
龙岩市| 安陆市| 陵川县| 孟津县| 武平县| 海晏县| 明光市| 吴旗县| 盐津县| 翁牛特旗| 德昌县| 通州市| 青铜峡市| 东莞市| 越西县| 合作市| 威信县| 湾仔区| 恭城| 顺义区| 温泉县| 江华| 临漳县| 霍城县| 黑水县| 安吉县| 高碑店市| 盘锦市| 新宾| 开平市| 友谊县| 平果县| 高雄市| 鄱阳县| 都江堰市| 九台市| 菏泽市| 宁夏| 贡山| 卓资县| 襄樊市|