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Cell and Bioscience

Cell and Bioscience

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Human epicardial organoids from pluripotent stem cells resemble fetal stage with potential cardiomyocyte- transdifferentiation

Published:17 January 2025 DOI: 10.1186/s13578-024-01339-w PMID: 39825425
Fanwen Wang,?Xinle Zou,?Huilin Zheng,?Tianci Kong,?Duanqing Pei

Abstract

Epicardium, the most outer mesothelium, exerts crucial functions in fetal heart development and adult heart regeneration. Here we use a three-step manipulation of WNT signalling entwined with BMP and RA signalling for generating a self-organized epicardial organoid that highly express with epicardium makers WT1 and TCF21 from human embryonic stem cells. After 8-days treatment of TGF-beta following by bFGF, cells enter into epithelium-mesenchymal transition and give rise to smooth muscle cells. Epicardium could also integrate and invade into mouse heart with SNAI1 expression, and give birth to numerous cardiomyocyte-like cells. Single-cell RNA seq unveils the heterogeneity and multipotency exhibited by epicardium-derived-cells and fetal-like epicardium. Meanwhile, extracellular matrix and growth factors secreted by epicardial organoid mimics the ecology of subepicardial space between the epicardium and cardiomyocytes. As such, this epicardial organoid offers a unique ground for investigating and exploring the potential of epicardium in heart development and regeneration.

Substances (14)

Materials
Procduct Name CAS Molecular Formula Supplier Price
Y27632 (hydrochloride) 129830-38-2 C14H23Cl2N3O 226 suppliers $23.00-$5472.00
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