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Cell stem cell

Cell stem cell

IF: 19.8
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Individualized patient tumor organoids faithfully preserve human brain tumor ecosystems and predict patient response to therapy

Published:11 February 2025 DOI: 10.1016/j.stem.2025.01.002
Tianping Peng, Xiujian Ma, Wei Hua, Changwen Wang, Youjun Chu, Meng Sun, Valentina Fermi, Stefan Hamelmann, Katharina Lindner, Chunxuan Shao, Julia Zaman, Weili Tian, Yue Zhuo, Yassin Harim, Nadja St?ffler, Linda Hammann, Qungen Xiao, Xiaoliang Jin, Rolf Warta, Catharina Lotsch, Ying Mao

Abstract

Tumor organoids are important tools for cancer research, but current models have drawbacks that limit their applications for predicting response to therapy. Here, we developed a fast, efficient, and complex culture system (IPTO, individualized patient tumor organoid) that accurately recapitulates the cellular and molecular pathology of human brain tumors. Patient-derived tumor explants were cultured in induced pluripotent stem cell (iPSC)-derived cerebral organoids, thus enabling culture of a wide range of human tumors in the central nervous system (CNS), including adult, pediatric, and metastatic brain cancers. Histopathological, genomic, epigenomic, and single-cell RNA sequencing (scRNA-seq) analyses demonstrated that the IPTO model recapitulates cellular heterogeneity and molecular features of original tumors. Crucially, we showed that the IPTO model predicts patient-specific drug responses, including resistance mechanisms, in a prospective patient cohort. Collectively, the IPTO model represents a major breakthrough in preclinical modeling of human cancers,?which provides a path toward personalized cancer therapy.

Substances (16)

Materials
Procduct Name CAS Molecular Formula Supplier Price
Carboplatin 41575-94-4 C6H12N2O4Pt 706 suppliers $17.00-$3650.00
Carboplatin 41575-94-4 C6H12N2O4Pt 706 suppliers $17.00-$3650.00
Carboplatin 41575-94-4 C6H12N2O4Pt 706 suppliers $17.00-$3650.00
Carboplatin 41575-94-4 C6H12N2O4Pt 706 suppliers $17.00-$3650.00
Pemetrexed Disodium 150399-23-8 C20H22N5NaO6 495 suppliers $5.00-$1390.00
Pemetrexed Disodium 150399-23-8 C20H22N5NaO6 495 suppliers $5.00-$1390.00
Pemetrexed Disodium 150399-23-8 C20H22N5NaO6 495 suppliers $5.00-$1390.00
Pemetrexed Disodium 150399-23-8 C20H22N5NaO6 495 suppliers $5.00-$1390.00
AZD-9291 1421373-65-0 C28H33N7O2 429 suppliers $4.00-$1800.00
AZD-9291 1421373-65-0 C28H33N7O2 429 suppliers $4.00-$1800.00

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