一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

ChemicalBook >> journal list >> Cell stem cell >>article
Cell stem cell

Cell stem cell

IF: 19.8
Download PDF

A pancreatic cancer organoid biobank links multi-omics signatures to therapeutic response and clinical evaluation of statin combination therapy

Published:13 August 2025 DOI: 10.1016/j.stem.2025.07.008
Yunguang Li, Shijie Tang, Huan Wang, Hongwen Zhu, Yurun Lu, Yehan Zhang, Shiwei Guo, Juan He, Yikai Li, Yi Zhang, Xiaohan Shi, Yuanxiang Miao, Chaoliang Zhong, Yiqin Zhu, Yi Ju, Yuejia Liu, Maoyuan Sun, Yong Wang, Luonan Chen, Hu Zhou, Dong Gao

Abstract

Chemotherapy remains the primary treatment for pancreatic ductal adenocarcinoma (PDAC), but most patients ultimately develop resistance. Here, we established 260 pancreatic cancer organoid lines, followed by extensive multi-omics profiling and therapeutic sensitivity assessments. Integrated analyses uncovered 6 novel coding and 35 noncoding driver candidates. We discovered 2,794 multi-omics features associated with drug sensitivity and 322 features linked to radiation sensitivity. Pharmacogenomic analyses revealed that chemoresistant organoids exhibited enrichment in protein glycosylation and cholesterol metabolism pathways. Notably, statins effectively targeted chemoresistant PDAC organoids. Statin treatment attenuated protein glycosylation, cholesterol levels, and the epithelial-to-mesenchymal transition (EMT) signature in PDAC organoids. We conducted a single-center, single-arm, phase 2 clinical trial (NCT06241352) combining atorvastatin with chemotherapy in patients with advanced pancreatic cancer. Among 37 patients, 26 (70.3%) demonstrated a response, with tumor markers decreasing by more than 20%, suggesting durable responses and potential clinical benefits in this challenging patient population.

Substances (430)

Materials
Procduct Name CAS Molecular Formula Supplier Price
Rapamycin 53123-88-9 C51H79NO13 1033 suppliers $9.00-$6160.00
Rapamycin 53123-88-9 C51H79NO13 1033 suppliers $9.00-$6160.00
Rapamycin 53123-88-9 C51H79NO13 1033 suppliers $9.00-$6160.00
Rapamycin 53123-88-9 C51H79NO13 1033 suppliers $9.00-$6160.00
Simvastatin 79902-63-9 C25H38O5 867 suppliers $5.00-$4900.00
Simvastatin 79902-63-9 C25H38O5 867 suppliers $5.00-$4900.00
Simvastatin 79902-63-9 C25H38O5 867 suppliers $5.00-$4900.00
Simvastatin 79902-63-9 C25H38O5 867 suppliers $5.00-$4900.00
Cytarabine 147-94-4 C9H13N3O5 793 suppliers $5.00-$1025.00
Cytarabine 147-94-4 C9H13N3O5 793 suppliers $5.00-$1025.00

Similar articles

IF:9.1

Multi-targeted prevention of cancer by sulforaphane

Cancer letters John D. Clarke , Roderick H. Dashwood ,etc Published: 8 October 2008
IF:15.1

Pectin in cancer therapy: A review

Trends in Food Science & Technology Wenbo Zhang , Ping Xu ,etc Published: 1 August 2015
三台县| 梓潼县| 安宁市| 思南县| 秦皇岛市| 大兴区| 岳西县| 北川| 台南市| 高尔夫| 岑溪市| 东阳市| 周至县| 佳木斯市| 吉木萨尔县| 手机| 宁阳县| 读书| 滨海县| 南雄市| 英吉沙县| 景德镇市| 旬邑县| 贺兰县| 张北县| 伊金霍洛旗| 兴城市| 仙游县| 义乌市| 颍上县| 宁安市| 呼伦贝尔市| 台州市| 固安县| 永平县| 西畴县| 罗定市| 沛县| 宝坻区| 德庆县| 海安县|